GR 127935 reduces basal locomotor activity and prevents RU 24969-, but not D-amphetamine-induced hyperlocomotion, in the Wistar-Kyoto hyperactive (WKHA) rat
| Autor: | Hélène Courvoisier, Pierre Mormède, Marie-Pierre Moisan, Francis Chaouloff |
|---|---|
| Přispěvatelé: | Neurogénétique et stress, Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM), PERIGNON, Alain |
| Rok vydání: | 1999 |
| Předmět: |
Male
Indoles MESH: Receptor Serotonin 5-HT1B [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology [SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior MESH: Piperazines Locomotor activity Rats Inbred WKY Piperazines MESH: Serotonin Antagonists MESH: Dose-Response Relationship Drug 0302 clinical medicine MESH: Animals Receptor MESH: Indoles 0303 health sciences Oxadiazoles [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior Chemistry [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences Receptor antagonist MESH: Serotonin Receptor Agonists MESH: Motor Activity Serotonin Receptor Agonists Receptor Serotonin 5-HT1B Serotonin Antagonists medicine.symptom MESH: Rats Inbred WKY medicine.drug Agonist medicine.medical_specialty MESH: Receptors Serotonin Dextroamphetamine MESH: Rats medicine.drug_class Motor Activity MESH: Central Nervous System Stimulants MESH: Dextroamphetamine 03 medical and health sciences Internal medicine medicine Animals Amphetamine GR-127935 030304 developmental biology Pharmacology Dose-Response Relationship Drug MESH: Oxadiazoles [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology MESH: Male Rats Endocrinology Mechanism of action Receptors Serotonin Central Nervous System Stimulants Serotonin MESH: Receptors Serotonin 5-HT1 Receptors Serotonin 5-HT1 [SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences 030217 neurology & neurosurgery |
| Zdroj: | Psychopharmacology Psychopharmacology, Springer Verlag, 1999, 141 (3), pp.326-331. ⟨10.1007/s002130050841⟩ |
| ISSN: | 0033-3158 1432-2072 |
| DOI: | 10.1007/s002130050841⟩ |
| Popis: | International audience; The hyperlocomotor effect of the serotonin (5-HT)1A,B receptor agonist 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (RU 24969) has been repeatedly reported. However, 5-HT1A receptors, 5-HT1B receptors (or both) have been claimed to mediate this effect of RU 24969. These contradictory data possibly arise from protocol differences, especially those related to animal species, drugs, and activity assessment. Herein, the influence of a pretreatment with the selective 5-HT1B,D receptor antagonist N-[4-methoxy3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5me thyl-1,2,4-oxadiozol-3-yl)-biphenyl-4-carboxamide (GR 127935; 1, 3.3 and 10 mg/kg IP) on the hyperlocomotor effect of a 5 mg/kg (IP) dose of RU 24969 was studied in Wistar-Kyoto Hyperactive (WKHA) rats. In a first series of experiments, it was confirmed that RU 24969 (2.5 and 5 mg/kg), administered 10 min after the onset of activity recordings, increases locomotion dose-dependently (cage crossings). In a second series of experiments, administration of GR 127935 10 min after the onset of activity recordings promoted a dose-dependent decrease in basal activity (and rearings) and prevented (3.3 and 10 mg/kg) RU 24969-elicited locomotor activity. On the other hand, GR 127935 was ineffective against RU 24969-induced inhibition of rearings. Lastly, it was observed that 3.3 mg/kg GR 127935 did not affect the number of cage crossings and rearings displayed by rats administered 1.5 mg/kg D-amphetamine. This study shows that 5-HT1B receptors play a major role in the hyperlocomotor effect of RU 24969, at least under our experimental setting. Whether these receptors also play a tonic role in the high locomotor activity displayed by WKHA rats remains to be determined. |
| Databáze: | OpenAIRE |
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