| Autor: |
Jean-Claude, Mwanza, Samantha E, Tulenko, Donald L, Budenz, Leon W, Herndon, Alyson, Hall, Graham, Hay-Smith, Hanna Y, Kim, Elizabeth, Mathenge, Alexander, Spratt, Angelo P, Tanna, Keith, Barton |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of Glaucoma. 31:503-510 |
| ISSN: |
1057-0829 |
| DOI: |
10.1097/ijg.0000000000001984 |
| Popis: |
The annual incidence of glaucoma progression (9.7%) and rates of visual field mean deviation (MD) change in progressors (-1.02±0.06 dB/y) are high in a small cohort of urban Ghanaians.To report the incidence of glaucoma progression and the rate of visual field deterioration in a small cohort of Ghanaians.One hundred ten subjects (204 eyes) diagnosed with glaucoma at a baseline population-based screening examination were re-examined a mean of 8.3±0.8 years later. Eyes were classified as having progressed if the optic disc alone, visual field alone or both showed significant glaucomatous changes on follow-up. Visual field MD was used to calculate the rate of visual field progression.Progression was observed in 89 (80.9%, 9.7%/year) subjects (130 eyes). Progression occurred in 32 (31.7%, 3.8%/year) subjects by optic disc alone (46 eyes), 38 (44.7%, 5.4%/year) subjects by visual field alone (58 eyes), and 19 (25.0%, 3.0%/year) subjects by both modalities (26 eyes). The average rate of change in MD differed significantly between progressors (-1.02±1.06 dB/y) and nonprogressors (+0.089±0.49 dB/y), P =0.001. The rate of visual field worsening was greater among those who were classified as having progressed by both structure and function (-1.29±0.68 dB/y) and by function alone (-1.21±1.20 dB/y) than by structure alone (-0.55±0.76 dB/y). Progression was significantly associated with older age [odds ratio (OR), 1.42; P0.001] and higher baseline intraocular pressure (OR, 1.18; P =0.002). Factors associated with rate of MD change were baseline older age (OR, 1.66; P =0.003), higher intraocular pressure (OR, 2.81; P =0.007), better visual field MD (OR, 1.41; P =0.004), and systemic hypertension (OR, 1.15; P =0.029).The incidence and rate of visual field progression are high in this longitudinal study of Ghanaian subjects with glaucoma. The findings may have important clinical and public health policy ramifications. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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