Repetitive transcranial magnetic stimulation reduces remote apoptotic cell death and inflammation after focal brain injury

Autor: Valeria Carola, Elisa Bisicchia, Marco Molinari, Veronica Ghiglieri, Laura Latini, Fabrizio Cacace, Valeria Sasso, Maria Teresa Viscomi
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Neurology
medicine.medical_treatment
Messenger
Wistar
Apoptosis
neuroinflammation
0302 clinical medicine
Remote degeneration
Glial activation
Glial fibrillary acidic protein
biology
General Neuroscience
Microfilament Proteins
Cytochromes c
Transcranial Magnetic Stimulation
Neuroprotection
medicine.anatomical_structure
Transcranial magnetic stimulation
inflammation
apoptosis
remote degeneration
glial activation
neuroprotection
Neuroglia
Settore BIO/17 - ISTOLOGIA
medicine.symptom
medicine.medical_specialty
Central nervous system
Immunology
Short Report
Inflammation
Brain damage
03 medical and health sciences
Cellular and Molecular Neuroscience
Glial Fibrillary Acidic Protein
medicine
Animals
RNA
Messenger
Rats
Wistar
Neuroscience (all)
business.industry
Animal
Calcium-Binding Proteins
Recovery of Function
Rats
Disease Models
Animal
030104 developmental biology
nervous system
Gene Expression Regulation
Brain Injuries
Phosphopyruvate Hydratase
Disease Models
biology.protein
RNA
business
Neuroscience
030217 neurology & neurosurgery
Zdroj: Europe PubMed Central
Journal of Neuroinflammation
Popis: Background After focal brain injuries occur, in addition to the effects that are attributable to the primary site of damage, the resulting functional impairments depend highly on changes that occur in regions that are remote but functionally connected to the site of injury. Such effects are associated with apoptotic and inflammatory cascades and are considered to be important predictors of outcome. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive technique that is used to treat various central nervous system (CNS) pathologies and enhance functional recovery after brain damage. Objective This study examined the efficacy of rTMS in mitigating remote degeneration and inflammation and in improving functional recovery in a model of focal brain damage. Methods Rats that were undergoing hemicerebellectomy (HCb) were treated with an rTMS protocol for 7 days, and neuronal death indices, glial activation, and functional recovery were assessed. Results rTMS significantly reduced neuronal death and glial activation in remote regions and improved functional recovery. Conclusions Our finding opens up a completely new scenario for exploiting the potential of rTMS as an anti-apoptotic and anti-inflammatory treatment. Electronic supplementary material The online version of this article (doi:10.1186/s12974-016-0616-5) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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