Dietary docosahexaenoic acid supplementation alters select physiological endocannabinoid-system metabolites in brain and plasma
| Autor: | John S. Williams, Lakshmipathi Pandarinathan, JodiAnne T. Wood, David R. Janero, Carol J. Lammi-Keefe, Alexandros Makriyannis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Glycerol
Male medicine.medical_specialty Time Factors Docosahexaenoic Acids Context (language use) QD415-436 Biology nutritional fatty-acid supplementation Biochemistry Mice Endocrinology Tandem Mass Spectrometry Internal medicine Cannabinoid Receptor Modulators medicine Metabolome Animals anandamide mouse chemistry.chemical_classification Body Weight Brain Fatty acid Lipid metabolism Cell Biology Lipid Metabolism Endocannabinoid system Eicosapentaenoic acid metabolomics 2-arachidonoylglycerol chemistry Ethanolamines Docosahexaenoic acid Dietary Supplements Fatty Acids Unsaturated lipidomics lipids (amino acids peptides and proteins) Chromatography Liquid Endocannabinoids Research Article Polyunsaturated fatty acid |
| Zdroj: | Journal of Lipid Research, Vol 51, Iss 6, Pp 1416-1423 (2010) |
| ISSN: | 0022-2275 |
| Popis: | The endocannabinoid metabolome consists of a growing, (patho)physiologically important family of fatty-acid derived signaling lipids. Diet is a major source of fatty acid substrate for mammalian endocannabinoid biosynthesis. The principal long-chain PUFA found in mammalian brain, docosahexaenoic acid (DHA), supports neurological function, retinal development, and overall health. The extent to which dietary DHA supplementation influences endocannabinoid-related metabolites in brain, within the context of the circulating endocannabinoid profile, is currently unknown. We report the first lipidomic analysis of acute 2-week DHA dietary supplementation effects on the physiological state of 15 fatty-acid, N-acylethanolamine, and glycerol-ester endocannabinoid metabolome constituents in murine plasma and brain. The DHA-rich diet markedly elevated DHA, eicosapentaenoic acid, 2-eicosapentanoylglycerol (EPG), and docosahexanoylethanolamine in both compartments. Dietary DHA enhancement generally affected the synthesis of the N-acyl-ethanolamine and glycerol-ester metabolites to favor the docosahexaenoic and eicosapentaenoic vs. arachidonoyl and oleoyl homologs in both brain and plasma. The greater overall responsiveness of the endocannabinoid metabolome in plasma versus brain may reflect a more circumscribed homeostatic response range of brain lipids to dietary DHA supplementation. The ability of short-term DHA enhancement to modulate select constituents of the physiological brain and plasma endocannabinoid metabolomes carries metabolic and therapeutic implications. |
| Databáze: | OpenAIRE |
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