Possible Obesogenic Effects of Bisphenols Accumulation in the Human Brain
| Autor: | Xanthi Andrianou, Bruce H. R. Wolffenbuttel, Dick F. Swaab, Thomas P van der Meer, Jana V. van Vliet-Ostaptchouk, Pantelis Charisiadis, Konstantinos C. Makris, Wilfred F. A. den Dunnen |
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| Přispěvatelé: | Academic Medical Center, Netherlands Institute for Neuroscience (NIN), Molecular Neuroscience and Ageing Research (MOLAR), Lifestyle Medicine (LM), Center for Liver, Digestive and Metabolic Diseases (CLDM) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
endocrine system
medicine.medical_specialty Bisphenol A Halogenation Bisphenol Hypothalamus lcsh:Medicine Endocrine Disruptors 010501 environmental sciences Grey matter 01 natural sciences Article Body Mass Index White matter 03 medical and health sciences chemistry.chemical_compound Phenols Internal medicine Journal Article medicine Humans Obesity Benzhydryl Compounds lcsh:Science 030304 developmental biology 0105 earth and related environmental sciences 0303 health sciences Multidisciplinary urogenital system Chemistry lcsh:R Brain Environmental Exposure Human brain medicine.disease White Matter medicine.anatomical_structure Endocrinology Adipose Tissue Environmental Pollutants lcsh:Q Body mass index hormones hormone substitutes and hormone antagonists Chlorophenols |
| Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018) Scientific reports, 8(1):8186. Nature Publishing Group Scientific Reports, 8(1). Nature Publishing Group Scientific Reports Scientific Reports, 8(1):8186. Nature Publishing Group |
| ISSN: | 2045-2322 |
| Popis: | Evidence of bisphenols’ obesogenic effects on humans is mixed and inconsistent. We aimed to explore the presence of bisphenol A (BPA), bisphenol F (BPF) and chlorinated BPA (ClBPA), collectively called the bisphenols, in different brain regions and their association with obesity using post-mortem hypothalamic and white matter brain material from twelve pairs of obese (body mass index (BMI) >30 kg/m2) and normal-weight individuals (BMI 2). Mean ratios of hypothalamus:white matter for BPA, BPF and ClBPA were 1.5, 0.92, 0.95, respectively, suggesting no preferential accumulation of the bisphenols in the grey matter (hypothalamic) or white matter-enriched brain areas. We observed differences in hypothalamic concentrations among the bisphenols, with highest median level detected for ClBPA (median: 2.4 ng/g), followed by BPF (2.2 ng/g) and BPA (1.2 ng/g); similar ranking was observed for the white matter samples (median for: ClBPA-2.5 ng/g, BPF-2.3 ng/g, and BPA-1.0 ng/g). Furthermore, all bisphenol concentrations, except for white-matter BPF were associated with obesity (p |
| Databáze: | OpenAIRE |
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