Preclinical antitoxic properties of Spirulina (Arthrospira)
| Autor: | Luis Fabila-Castillo, Angélica Perez-Juarez, Elizdath Martínez-Galero, Germán Chamorro, Gabriela Gutiérrez-Salmeán, Ricardo Pérez-Pastén |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Antioxidant
medicine.medical_treatment Antidotes Hexachlorocyclohexane Pharmaceutical Science Antioxidants Toxicology chemistry.chemical_compound 0404 agricultural biotechnology Occupational Exposure Drug Discovery medicine Spirulina Animals Humans Pharmacology Spirulina (genus) biology Traditional medicine Chemistry Poisoning 04 agricultural and veterinary sciences General Medicine Environmental Exposure biology.organism_classification 040401 food science Complementary and alternative medicine Molecular Medicine Environmental Pollutants Arthrospira Lindane |
| Zdroj: | Pharmaceutical biology. 54(8) |
| ISSN: | 1744-5116 |
| Popis: | Spirulina (Arthrospira) exerts a wide spectrum of pharmacological activities which are mainly attributed to its antioxidant effect. However, Spirulina has also been reported (both in preclinical and in clinical scenarios) to exhibit other bioactive effects, including an antitoxic potential.We performed a systematic review of the literature, conducted in TOXNET, PubMed/MEDLINE, and Science Direct-Scopus; all available years were included. Searching criteria included the effects of Spirulina on experimental poisonings from arsenic, cadmium, carbon tetrachloride, deltamethrin, fluoride, hexachlorocyclohexane, iron, lead, lindane, and mercury.In all cases, it was established that the blue-green alga, and its isolated compounds, effectively counteracted these pollutants toxic effects on the exposed organisms. Some molecular mechanisms are proposed, although they have not been fully elucidated yet.Spirulina could be a useful coadjuvant agent within clinical practice for treatment of these or other pollutants poisonings. |
| Databáze: | OpenAIRE |
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