Clusterin expression in medullary thyroid carcinoma is inversely correlated with the presence of lymph node metastases
| Autor: | Jerzy Klijanienko, Malika Bennis, Pierre-Yves Boëlle, André Balaton, Marine Lefevre, Najat Mourra, Charles Lepine, Fabrice Menegaux, Frédérique Tissier, Béatrix Cochand-Priollet |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Pathology medicine.medical_specialty Paris Adolescent Biopsy Neuroendocrine tumors Pathology and Forensic Medicine Thyroid carcinoma 03 medical and health sciences Young Adult 0302 clinical medicine Biomarkers Tumor Medicine Neoplasm Humans Thyroid Neoplasms Lymph node Aged Aged 80 and over Hyperplasia Clusterin biology business.industry Thyroid Middle Aged medicine.disease Prognosis Immunohistochemistry Carcinoma Neuroendocrine 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Lymphatic Metastasis biology.protein Female Lymph Nodes business |
| Zdroj: | Human pathology. 64 |
| ISSN: | 1532-8392 |
| Popis: | Clusterin (CLU) is a sulfated glycoprotein implicated in many physiological and pathological processes, including tumorigenesis. Several studies have reported the overexpression of CLU in human neoplasm, examined by immunohistochemistry. However, there are no extensive data on its role in the thyroid. Here we investigate CLU expression in thyroid tumors, and the potential correlation between this expression and clinicopathological parameters. Immunohistochemistry with anti-CLU was performed on paraffin sections from 39 thyroid tumors. Only medullary thyroid carcinomas (MTCs) were positive (n = 5). To confirm these results, 130 further cases (including 4 C-cell hyperplasia), their matched lymph node metastases (46 cases), and lymph node recurrences (10 cases) were analyzed. All MTCs were subdivided according to World Health Organization classification. Cytoplasmic positivity was scored qualitatively (weak, moderate, strong) and quantitatively on a 5-tier scale from 0, 1+ (10% of cells positive) to 5+ (75%). Statistical analysis was performed. CLU was expressed in normal C cells, C-cell hyperplasia, all MTCs, their lymph node metastases, and recurrences. There was a strong association between CLU score and the cellular type (P.004). CLU score was inversely correlated with the presence of lymph node metastases (P.0001). There were no differences between primary and metastatic or recurrent tumors. CLU expression is related to the cellular type and inversely correlated with the presence of lymph node metastases, which could represent a new positive prognostic factor. |
| Databáze: | OpenAIRE |
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