Screening of Glucose-6-Phosphate Dehydrogenase Deficiency in Cord Blood
Autor: | Yasemin Karal, Can Acipayam, Betül Biner Orhaner |
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Jazyk: | angličtina |
Rok vydání: | 2014 |
Předmět: |
Neonate
Jaundice medicine.medical_specialty Cord Glucose-6-phosphate dehydrogenase business.industry lcsh:R lcsh:Medicine Dehydrogenase medicine.disease chemistry.chemical_compound Endocrinology Biochemistry Glucose 6-phosphate chemistry Cord blood Internal medicine medicine business Glucose-6-phosphate dehydrogenase deficiency |
Zdroj: | Journal of Clinical and Analytical Medicine, Vol 4, Iss 141, Pp 4-8 (2014) |
ISSN: | 1309-2014 1309-0720 |
Popis: | Aim: Glucose-6-phosphate dehydrogenase deficiency is an important factor in etiology of pathologic neonatal jaundice. The aim of this study was to indicate the significance of screening glucose-6-phosphate dehydrogenase deficiency in the cord blood of neonates and the frequency of this deficiency in the etiology of neonatal hyperbilirubinemia. Material and Method: The study was performed consecutive 1015 neonates were included. Five hundred fifty six (54.8%) of them were male and 459 (45.2%) were female. The following parameters were recorded: Gender, birth weight, birth height, head circumference and gestational age. The glucose-6-phosphate dehydrogenase level of neonates were measured with quantitative method in cord blood. Also, hemoglobine, hematocrite, red blood cell count and blood group were measured. The following parameters were recorded in cases with jaundice: exchange transfusion, phototherapy, physiologic and pathologic jaundice, peak bilirubin day, maximum bilirubin level, total bilirubin level at the first day of jaundice, beginning time of jaundice. Results: Enzyme deficiency was detected in 133 (13.1%) of neonates and 76 (57%) of them were male, 57 (43%) were female. Significant difference was detected in low glucose-6-phosphate dehydrogenase enzyme level with jaundice group for total bilirubin level at the first day of jaundice, maximum total bilirubin level and pathologic jaundice (p |
Databáze: | OpenAIRE |
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