Early adverse events, HPA activity and rostral anterior cingulate volume in MDD
| Autor: | Zhaohua Ding, John C. Gore, Richard C. Shelton, Steven D. Hollon, Michael T. Treadway, Merida M. Grant |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Hydrocortisone Science Physiology Grey matter Biology Gyrus Cinguli behavioral disciplines and activities 03 medical and health sciences Young Adult 0302 clinical medicine medicine Humans Young adult Psychiatry Adverse effect Saliva Depression (differential diagnoses) Depressive Disorder Major Nerve Fibers Unmyelinated Multidisciplinary Mental Health/Mood Disorders Case-control study Voxel-based morphometry Organ Size Middle Aged medicine.disease Mental Health/Psychology 030227 psychiatry medicine.anatomical_structure Case-Control Studies Major depressive disorder Mental Health/Psychopharmacology Medicine 030217 neurology & neurosurgery medicine.drug Research Article |
| Zdroj: | PLoS ONE, Vol 4, Iss 3, p e4887 (2009) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | BackgroundPrior studies have independently reported associations between major depressive disorder (MDD), elevated cortisol concentrations, early adverse events and region-specific decreases in grey matter volume, but the relationships among these variables are unclear. In the present study, we sought to evaluate the relationships between grey matter volume, early adverse events and cortisol levels in MDD.Methods/resultsGrey matter volume was compared between 19 controls and 19 individuals with MDD using voxel-based morphometry. A history of early adverse events was assessed using the Childhood Trauma Questionnaire. Subjects also provided salivary cortisol samples. Depressed patients showed decreased grey matter volume in the rostral ACC as compared to controls. Rostral ACC volume was inversely correlated with both cortisol and early adverse events.ConclusionsThese findings suggest a key relationship between ACC morphology, a history of early adverse events and circulating cortisol in the pathophysiology of MDD. |
| Databáze: | OpenAIRE |
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