Low concentrations of folate, not hyperhomocysteinemia, are associated with carotid intima-media thickness
Autor: | Petra Verhoef, Frans J. Kok, Evert G. Schouten, Michiel L. Bots, Jane Durga |
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Rok vydání: | 2005 |
Předmět: |
Carotid Artery Diseases
Male Nutrition and Disease Homocysteine Arteriosclerosis Distension Gastroenterology chemistry.chemical_compound Risk Factors Voeding en Ziekte stage renal-disease risk education.field_of_study biology Middle Aged large arteries cardiovascular system Female general-population Cardiology and Cardiovascular Medicine medicine.medical_specialty Hyperhomocysteinemia 5 10-Methylenetetrahydrofolate Reductase (FADH2) Population Folic Acid Internal medicine medicine Humans cardiovascular diseases education coronary Aged VLAG Global Nutrition Wereldvoeding Polymorphism Genetic business.industry medicine.disease methylenetetrahydrofolate reductase heart-disease Surgery B vitamins Cross-Sectional Studies Intima-media thickness chemistry Methylenetetrahydrofolate reductase biology.protein Arterial stiffness Vascular Resistance atherosclerosis mutation Tunica Intima plasma homocysteine business Biomarkers |
Zdroj: | Atherosclerosis, 179(2), 285-292 Atherosclerosis 179 (2005) 2 |
ISSN: | 0021-9150 |
Popis: | Aim: We examined whether total homocysteine, B vitamins and the 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T polymorphism are related to common carotid intima-media thickness, a marker of atherosclerosis, and carotid distension, a marker of arterial stiffness. Methods: We used cross-sectional data from 819 individuals aged 50–70 years. B-mode ultrasound of the distal common carotid arteries was performed to determine maximum carotid intima-media thickness, mean carotid intima-media thickness and distension. Results: Carotid intima-media thickness and distension did not differ across homocysteine, serum folate, vitamin B 6 and vitamin B 12 quartiles or between MTHFR C677T genotype. Erythrocyte folate was independently associated with maximum carotid intima-media thickness (mean difference first versus third quartile, 0.03mm, 95% CI 0.004–0.06mm; first versus fourth quartile, 0.03mm, 95% CI −0.002 to 0.06mm). Further adjustment for homocysteine did not affect this association. Folate deficient subjects had greater maximum carotid intima-media thickness than those with high-normal folate concentrations (serum folate: mean difference 0.05mm, 95% CI 0.01–0.08mm; erythrocyte folate: mean difference 0.04mm, 95% CI −0.03 to 0.11mm). Conclusion: Low folate concentrations, independent of hyperhomocysteinemia, may promote atherogenesis. Our findings confirm the null association of homocysteine with carotid intima-media thickness observed in other population-based studies, suggesting that hyperhomocysteinemia does not perpetuate atherosclerosis or arterial stiffness. |
Databáze: | OpenAIRE |
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