Low concentrations of folate, not hyperhomocysteinemia, are associated with carotid intima-media thickness

Autor: Petra Verhoef, Frans J. Kok, Evert G. Schouten, Michiel L. Bots, Jane Durga
Rok vydání: 2005
Předmět:
Carotid Artery Diseases
Male
Nutrition and Disease
Homocysteine
Arteriosclerosis
Distension
Gastroenterology
chemistry.chemical_compound
Risk Factors
Voeding en Ziekte
stage renal-disease
risk
education.field_of_study
biology
Middle Aged
large arteries
cardiovascular system
Female
general-population
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
Hyperhomocysteinemia
5
10-Methylenetetrahydrofolate Reductase (FADH2)
Population
Folic Acid
Internal medicine
medicine
Humans
cardiovascular diseases
education
coronary
Aged
VLAG
Global Nutrition
Wereldvoeding
Polymorphism
Genetic
business.industry
medicine.disease
methylenetetrahydrofolate reductase
heart-disease
Surgery
B vitamins
Cross-Sectional Studies
Intima-media thickness
chemistry
Methylenetetrahydrofolate reductase
biology.protein
Arterial stiffness
Vascular Resistance
atherosclerosis
mutation
Tunica Intima
plasma homocysteine
business
Biomarkers
Zdroj: Atherosclerosis, 179(2), 285-292
Atherosclerosis 179 (2005) 2
ISSN: 0021-9150
Popis: Aim: We examined whether total homocysteine, B vitamins and the 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T polymorphism are related to common carotid intima-media thickness, a marker of atherosclerosis, and carotid distension, a marker of arterial stiffness. Methods: We used cross-sectional data from 819 individuals aged 50–70 years. B-mode ultrasound of the distal common carotid arteries was performed to determine maximum carotid intima-media thickness, mean carotid intima-media thickness and distension. Results: Carotid intima-media thickness and distension did not differ across homocysteine, serum folate, vitamin B 6 and vitamin B 12 quartiles or between MTHFR C677T genotype. Erythrocyte folate was independently associated with maximum carotid intima-media thickness (mean difference first versus third quartile, 0.03mm, 95% CI 0.004–0.06mm; first versus fourth quartile, 0.03mm, 95% CI −0.002 to 0.06mm). Further adjustment for homocysteine did not affect this association. Folate deficient subjects had greater maximum carotid intima-media thickness than those with high-normal folate concentrations (serum folate: mean difference 0.05mm, 95% CI 0.01–0.08mm; erythrocyte folate: mean difference 0.04mm, 95% CI −0.03 to 0.11mm). Conclusion: Low folate concentrations, independent of hyperhomocysteinemia, may promote atherogenesis. Our findings confirm the null association of homocysteine with carotid intima-media thickness observed in other population-based studies, suggesting that hyperhomocysteinemia does not perpetuate atherosclerosis or arterial stiffness.
Databáze: OpenAIRE
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