Response to Comment on Russell-Jones et al. Diabetes Care 2017;40:943-950. Comment on Bowering et al. Diabetes Care 2017;40:951-957
| Autor: | Keith Bowering, Bruce W. Bode, David Russell-Jones |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Advanced and Specialized Nursing
Pediatrics medicine.medical_specialty Gastric emptying business.industry Endocrinology Diabetes and Metabolism Insulin medicine.medical_treatment 030209 endocrinology & metabolism Hypoglycemia medicine.disease Insulin aspart 03 medical and health sciences 0302 clinical medicine Postprandial Diabetes Mellitus Type 2 Diabetes mellitus Internal Medicine medicine Humans 030212 general & internal medicine Dosing business Glycemic medicine.drug |
| Zdroj: | Diabetes care. 41(3) |
| ISSN: | 1935-5548 |
| Popis: | We appreciate the relevant comments raised by Wu et al. (1) regarding the challenges faced by clinicians in safely achieving postprandial, and overall, glycemic control for patients with diabetes in the face of individual needs and physiological variation (including varying rates of gastric emptying/gastroparesis). Increasing awareness and understanding of factors affecting the complex physiology of postprandial glucose regulation, together with an understanding of the clinical pharmacological profile, are key in guiding appropriate dosing and timing of any mealtime insulin therapy. In the onset 1 and 2 trials, both mealtime (0–2 min before the meal) and postmeal dosing (20 min after the start of a meal investigated in onset 1) of fast-acting insulin aspart (faster aspart) demonstrated noninferior overall glycemic control compared with mealtime conventional insulin aspart. Importantly, no statistically significant differences in the overall rates of hypoglycemia were found in these trials … |
| Databáze: | OpenAIRE |
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