Interstitial brachytherapy alone after breast conserving surgery: interim results of a German-Austrian multicenter phase II trial
| Autor: | A. Resch, Sven Ackermann, Vratislav Strnad, Rolf Sauer, Guido Hildebrandt, Josef Hammer, Richard Pötter, Michael Lotter, Oliver J. Ott, Matthias W. Beckmann |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Brachytherapy Breast Neoplasms Breast cancer Germany Breast-conserving surgery Humans Medicine Radiology Nuclear Medicine and imaging Prospective Studies Prospective cohort study business.industry Cosmesis Perioperative Middle Aged Interim analysis medicine.disease Combined Modality Therapy Surgery Oncology Austria Female Complication business |
| Popis: | To evaluate the value of interstitial brachytherapy (iBT) alone in the treatment of low-risk breast cancer patients with regard to local control, side effects, and cosmesis.From November 2000 to January 2004, 176 patients with low-risk breast cancer were treated with iBT only. Patients were eligible for entering the study if: the tumor size was3 cm; resection margins were clear by at least 2 mm; there were no lymph node metastases or only one micrometastasis (pNo, pNmi); age was35 years; steroid hormone receptor was positive; and histologic grade was 1 or 2. Seventy-five percent of patients received pulsed-dose-rate brachytherapy (D(ref) = 50 Gy); 25% of patients received high-dose-rate brachytherapy (D(ref) = 32.0 Gy). An interim analysis is presented for all patients after an interim follow-up of 12 months, and for half the patient population with an interim follow-up of 21 months.All patients remained disease-free on the date of analysis. A perioperative complication breast infection was recorded for 1/176 (0.6%) patients. Late toxicity i.e., hypersensation, hyperpigmentation, fibrosis, or teleangiectasia was observed in 1-12% of all patients. Grade I Fibrosis was registered in 7.6% (13/172) and grade II in 7.0% (12/172) of evaluable patients. Similarly, grade I teleangiectasia was observed in 4.7% (8/172), grade II in 0.6% (1/172), and grade III also in 0.6% (1/172) of evaluable patients. Excellent or good cosmetic results have been observed in 92-95% of patients.Brachytherapy as monotherapy in low-risk breast cancer patients after breast-conserving surgery is an effective, precise treatment modality without perioperative morbidity, low acute, mild late toxicity, and yields good to excellent cosmetic results. |
| Databáze: | OpenAIRE |
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