Positive association between the course of vitamin D intake and bone mineral density at 36 years in man
| Autor: | Paul Lips, Jan C. Roos, Jos W. R. Twisk, Michiel R. de Boer, Christel E. van Dijk, Lando Lodewijk Joseph Koppes |
|---|---|
| Přispěvatelé: | TNO Kwaliteit van Leven, Public and occupational health, Radiology and nuclear medicine, Internal medicine, EMGO - Musculoskeletal health, Methodology and Applied Biostatistics, EMGO+ - Musculoskeletal Health |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Histology Bone density Adolescent Physiology Veilig en Gezond Werken Endocrinology Diabetes and Metabolism sex difference Osteoporosis vitamin D Young Adult Absorptiometry Photon Bone Density Internal medicine Vitamin D and neurology Bone mineral density Medicine follow up Humans controlled study human Young adult Workplace Dual-energy X-ray absorptiometry Femoral neck Nutrition Bone mineral dual energy X ray absorptiometry vitamin intake medicine.diagnostic_test vitamin blood level business.industry lumbar spine Confounding article medicine.disease medicine.anatomical_structure Endocrinology female Dietary Supplements Longitudinal Regression Analysis business dietary intake Young adults |
| Zdroj: | Bone, 44(3), 437-441. Elsevier Inc. Bone, 3, 44, 437-441 van Dijk, C E, de Boer, M R, Koppes, L L J, Roos, J C, Lips, P T A M & Twisk, J W R 2009, ' Positive association between the course of vitamin D intake and bone mineral density at 36 years in man ', Bone, vol. 44, no. 3, pp. 437-441 . https://doi.org/10.1016/j.bone.2008.10.055 |
| ISSN: | 8756-3282 |
| Popis: | Introduction: Studies on the association of vitamin D and bone mineral density (BMD) in adolescence and young adults have shown contrasting results. None of these studies have examined the course and baseline in vitamin D intake. The purpose of this study was to examine the association between baseline and the course of dietary vitamin D intake on the BMD. Methods: Vitamin D intake was assessed 3-8 times between the age of 13 and 36 years in 152 men and 168 women from the Amsterdam Growth and Health Longitudinal Study. The BMD of the femoral neck, lumbar spine, total hip and total body was measured at the age of 36 years with dual-energy X-ray absorptiometry. Linear regression analyses were used to determine the vitamin D intake pattern in time for each subject. The models provide a baseline, course and fluctuation of the vitamin D intake for each subject. These were used in separate regression analyses with the dependent variable BMD. Results: Mean baseline vitamin D was 6.86 (SD: 2.18) μg/day for men and 4.90 (1.19) μg/day for women. Mean course of vitamin D was - 0.10 (0.12) μg/day/year and - 0.05 (0.18) μg/day/year for men and women respectively. After adjustment for potential confounders and correcting for the other parameters of vitamin D intake, the associations between baseline vitamin D intake and BMD were significant in the total hip (0.018 g/cm2 per - 1 μg/day; 95% CI 0.001-0.035) and total body (0.015 per - 1 μg/day; 0.001-0.029). The course of vitamin D intake was associated with BMD in the lumbar spine (0.50 g/cm2 per - 1 μg/day/year; 0.130-0.867), femoral neck (0.42 g/cm2 per - 1 μg/day/year; 0.10-0.743), total body (0.34 g/cm2 per - 1 μg/day/year; 0.09-0.59) and total hip (0.44 g/cm2 per - 1 μg/day/year; 0.11-0.77) in men. No significant associations were found in women. Conclusion: In men, the level of vitamin D intake in adolescence and the course of vitamin D intake from adolescence into adulthood are positively related with BMD in adulthood. In women, however, no significant associations are found. © 2008 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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