Persistent aryl hydrocarbon receptor inducers increase with altitude, and estrogen-like disrupters are low in soils of the Alps
| Autor: | Ivo Offenthaler, Peter Weiss, Primoz Simončič, Toine F.H. Bovee, Gert Jakobi, Silke Bernhöft, Norbert Kräuchi, Franz Buegger, Bernhard Henkelmann, Wolfgang Moche, Manfred Kirchner, Karl-Werner Schramm, R. Bassan, Walkiria Levy |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
green fluorescent protein
Health Toxicology and Mutagenesis RIKILT - Business Unit Veiligheid & Gezondheid Estrogen receptor Endocrine Disruptors in-vitro Trees chemistry.chemical_compound Yeasts expression Environmental Chemistry Bioassay Ecotoxicology Animals Soil Pollutants Cells Cultured model biology Geography Altitude Polychlorinated biphenyl Estrogens General Medicine pesticides Pesticide Aryl hydrocarbon receptor Pollution Humus Rats Europe chemistry Gene Expression Regulation Receptors Aryl Hydrocarbon bioassay Environmental chemistry biology.protein RIKILT - Business Unit Safety & Health Biological Assay dibenzo-p-dioxin environment Polychlorinated dibenzofurans polychlorinated biphenyl toxicity equivalents |
| Zdroj: | Environmental Science and Pollution Research, 18(1), 99-110 Environmental Science and Pollution Research 18 (2011) 1 |
| ISSN: | 0944-1344 1400-1500 |
| Popis: | Soil samples from remote Alpine areas were analyzed for polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans and polychlorinated biphenyls by high-resolution gas chromatography/high-resolution gas spectrometry. Additionally, the EROD micro-assay and a genetically modified yeast estrogen bioassay were carried out to determine persistent aryl hydrocarbon receptors (AhR) and estrogen receptors (ER) agonists, respectively. Regarding the AhR agonists, the toxicity equivalents of analytical and EROD determined values were compared, targeting both altitude of samples and their soil organic content. The ratio between bioassay derived equivalents and analytical determinations suggested no significant contribution of unknown AhR inducers in these sampling sites and some antagonism in soils with relatively high PCB loading. More CYP1A1 expression was induced at the highest sites or about 1400-1500 m a.s.l. along the altitude profiles. Surprisingly, no clear tendencies with the soil organic content were found for dioxin-like compounds. Mean values obtained in the present study were for ER agonists, 2: 0.37±0.12ng 17ß-estradiol EQ g-1 dry soil [corrected] and 6.1 ± 4.2 pg TCDD-EQ g⁻¹ dry soil for AhR agonists.Low bioassay responses with a higher relative amount of ER disrupters than AhR inducers were detected,indicating the higher abundance of estrogen-like than persistent dioxin-like compounds in these forested areas [corrected]. |
| Databáze: | OpenAIRE |
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