Analgesic, antiinflammatory and CNS depressant activities of sesquiterpenes and a flavonoid glycoside from Polygonum viscosum
| Autor: | Khan Th, Satyajit D. Sarker, Mohammad A. Rashid, Kundu Jk, S. K. Datta, Chowdhury Mm, Lutfun Nahar, Bidyut K. Datta |
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| Rok vydání: | 2004 |
| Předmět: |
Polygonum
Magnetic Resonance Spectroscopy Spectrophotometry Infrared Analgesic Flavonoid Anti-Inflammatory Agents Pharmacology Motor Activity Carrageenan Polygonaceae Mass Spectrometry Terpene Rats Sprague-Dawley chemistry.chemical_compound Mice Reaction Time Animals Edema Glycosides Hot plate test Acetic Acid Pain Measurement chemistry.chemical_classification Flavonoids Analgesics biology Plant Extracts Glycoside Central Nervous System Depressants General Medicine biology.organism_classification Rats chemistry Spectrophotometry Ultraviolet Sesquiterpenes |
| Zdroj: | Die Pharmazie. 59(3) |
| ISSN: | 0031-7144 |
| Popis: | Analgesic, antiinflammatory and CNS depressant activities of four sesquiterpenes, viscosumic acid, viscozulenic acid, viscoazucine and viscoazulone, and a flavonoid glycoside, quercetin-3-O-(6''-feruloyl)-beta-D-galactopyranoside isolated form the aerial parts of Polygonum viscosum (Polygonaceae) have been assessed. All test compounds exhibited CNS depressant activity in open field test, all but viscoazulone showed analgesic activity in Eddy's hot plate test, all sesquiterpenes inhibited acetic acid induced abdominal writhing in mice, and all but viscoazucine and the flavonoid glycoside exhibited mild to moderate antiinflammatory effect on carrageenan induced rat paw edema. |
| Databáze: | OpenAIRE |
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