A Comparison of Different Staging Systems for Multiple Myeloma: Can the MRI Pattern Play a Prognostic Role?
| Autor: | Paolo Spinnato, Eugenio Salizzoni, Katia Mancuso, Michele Cavo, Cristina Nanni, Alberto Bazzocchi, Elena Zamagni, Giacomo Filonzi, Stefano Fanti |
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| Přispěvatelé: | Filonzi, Giacomo, Mancuso, Katia, Zamagni, Elena, Nanni, Cristina, Spinnato, Paolo, Cavo, Michele, Fanti, Stefano, Salizzoni, Eugenio, Bazzocchi, Alberto |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Response to therapy Durie-Salmon PLUS Contrast Media 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Bone Marrow Positron Emission Tomography Computed Tomography medicine Humans Radiology Nuclear Medicine and imaging Whole Body Imaging Staging system Multiple myeloma Aged Neoplasm Staging Retrospective Studies bone marrow pattern Pelvic MRI business.industry General Medicine staging Middle Aged medicine.disease Prognosis Magnetic Resonance Imaging Survival Rate medicine.anatomical_structure 030220 oncology & carcinogenesis Female Bone marrow Radiology business Multiple Myeloma MRI |
| Zdroj: | AJR. American journal of roentgenology. 209(1) |
| ISSN: | 1546-3141 |
| Popis: | The objective of this study is to compare the most recent systems for the staging of multiple myeloma (MM), the Durie-Salmon PLUS system and the International Staging System, according to patients' survival rates and response to therapy. Another objective is to verify whether patterns of bone marrow alteration on MRI (i.e., focal, diffuse, or variegated patterns) can provide prognostic information for patients with MM.We retrospectively enrolled 85 patients with MM who were monitored for a minimum of 6 years and who underwent contrast-enhanced spinal and pelvic MRI at 1.5 T and whole-body FDG PET/CT at the time of diagnosis. Patients underwent MM staging performed using both staging systems and were divided into groups on the basis of their MRI patterns. These patient groups were then compared in terms of survival, response to therapy, and duration of response.Both staging systems showed great capability in differentiating patients with a worse prognosis from patients with a better outcome, with the capability of both systems found to be statistically significant, albeit less statistically significant for the Durie-Salmon PLUS system (p = 0.010 vs p = 0.046, respectively). Patients with a focal pattern on MRI had a worse survival rate than did the patients with other MRI patterns (p = 0.032).These data indicate that both the International Staging System and the Durie-Salmon PLUS system have great potential for characterizing and stratifying MM to determine the survival outcome and therapy response of patients. Observation of a focal pattern on MRI seems to be associated with poorer survival. |
| Databáze: | OpenAIRE |
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