New nanoprobe for breast cancer cell imaging based on low-density lipoprotein
| Autor: | Omid Pourdakan, Neda Iranpour Anaraki, Bita Mehravi, Mojdeh Mohseni, Elham Mohammadi, Sepideh Safari, Alireza Ghasempour, Mehdi Mirzaei |
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| Rok vydání: | 2019 |
| Předmět: |
Chemical Phenomena
Biomedical Engineering Intracellular Space Pharmaceutical Science Medicine (miscellaneous) Nanoprobe Breast Neoplasms 02 engineering and technology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Breast cancer Medicine Humans business.industry Biological Transport General Medicine 021001 nanoscience & nanotechnology medicine.disease Magnetic Resonance Imaging Lipoproteins LDL chemistry 030220 oncology & carcinogenesis Low-density lipoprotein Cancer research MCF-7 Cells Nanoparticles lipids (amino acids peptides and proteins) Breast cancer cells 0210 nano-technology business Biotechnology Lipoprotein |
| Zdroj: | Artificial cells, nanomedicine, and biotechnology. 48(1) |
| ISSN: | 2169-141X |
| Popis: | Many malignant cancers have an increased demand for lipoprotein due to the requirement for lipids for the rapid proliferation of the tumours and which is met by the increased availability of LDL through upregulation of LDL transporters. This unique phenomenon is the basis for the use of LDL based nanoparticles for cell imaging. In this study, a novel MR-active LDL nanoparticle was synthesised as the MRI probes. This MR-active LDL was characterised by using different techniques including scanning electron microscopy (SEM), dynamic light scattering (DLS), Fourier-transform infra-red spectroscopy (FTIR) and magnetic resonance imaging (MRI). The intracellular uptake of Gd |
| Databáze: | OpenAIRE |
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