Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease
| Autor: | Sunil Jit R.J. Logantha, James O. Tellez, Mark R. Boyett, Eman S.H. Abd Allah, Cali Anderson, P. Mesirca, Natalie Chandler, Matthew K. Lancaster, Matteo E. Mangoni, Joseph Yanni, George Hart, Jonathan P. Ariyaratnam, Matthew Smith, Henggui Zhang, Robert S. Stephenson, Luke Stuart, Gwilym M. Morris, Claire Wilson, Xue Cai, Rudi Billeter, Alicia D'Souza, Annalisa Bucchi, Sandra C. Jones, Oliver J. Monfredi, Carol T. Bussey, Shu Nakao |
|---|---|
| Přispěvatelé: | IT University of Copenhagen |
| Rok vydání: | 2021 |
| Předmět: |
Cardiac arrhythmias
Biophysics Action Potentials Heart failure Disease 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Heart Rate Atrial Fibrillation medicine Humans Circadian rhythm Cardiac conduction system Molecular Biology Transcription factor ComputingMilieux_MISCELLANEOUS Sinoatrial Node 030304 developmental biology 0303 health sciences business.industry Atrial fibrillation medicine.disease Atrioventricular node Athletic training Ageing Autonomic nervous system medicine.anatomical_structure Atrioventricular Node Electrical conduction system of the heart business Neuroscience |
| Zdroj: | Progress in Biophysics and Molecular Biology Progress in Biophysics and Molecular Biology, Elsevier, 2021, 166, pp.61-85. ⟨10.1016/j.pbiomolbio.2021.06.008⟩ PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY Boyett, M, Yanni Gerges, J, Tellez, J O, Bucchi, A, Mesirca, P, Cai, X, Logantha, S J R J, Wilson, C, Anderson, C, Ariyaratnam, J, Stuart, L, Nakao, S, Allah, E A, Jones, S A, Lancaster, M, Stephenson, R S, Chandler, N, Smith, M, Bussey, C, Monfredi, O, Morris, G, Billeter, R, Mangoni, M E, Zhang, H, Hart, G & D'Souza, A 2021, ' Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease ', Progress in biophysics and molecular biology, vol. 166, pp. 61-85 . https://doi.org/10.1016/j.pbiomolbio.2021.06.008 |
| ISSN: | 0079-6107 |
| DOI: | 10.1016/j.pbiomolbio.2021.06.008 |
| Popis: | The funny current, I f, was first recorded in the heart 40 or more years ago by Dario DiFrancesco and others. Since then, we have learnt that I f plays an important role in pacemaking in the sinus node, the innate pacemaker of the heart, and more recently evidence has accumulated to show that I f may play an important role in action potential conduction through the atrioventricular (AV) node. Evidence has also accumulated to show that regulation of the transcription and translation of the underlying Hcn genes plays an important role in the regulation of sinus node pacemaking and AV node conduction under normal physiological conditions - in athletes, during the circadian rhythm, in pregnancy, and during postnatal development - as well as pathological states - ageing, heart failure, pulmonary hypertension, diabetes and atrial fibrillation. There may be yet more pathological conditions involving changes in the expression of the Hcn genes. Here, we review the role of I f and the underlying HCN channels in physiological and pathological changes of the sinus and AV nodes and we begin to explore the signalling pathways (microRNAs, transcription factors, GIRK4, the autonomic nervous system and inflammation) involved in this regulation. This review is dedicated to Dario DiFrancesco on his retirement. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect