| Autor: |
Deepak Kumar, Christina A. Rostad, Preeti Jaggi, D. Sofia Villacis Nunez, Chengyu Prince, Austin Lu, Laila Hussaini, Thinh H. Nguyen, Sakshi Malik, Lori A. Ponder, Sreekala P.V. Shenoy, Evan J. Anderson, Michael Briones, Ignacio Sanz, Sampath Prahalad, Shanmuganathan Chandrakasan |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of Allergy and Clinical Immunology. 149:1592-1606.e16 |
| ISSN: |
0091-6749 |
| DOI: |
10.1016/j.jaci.2022.02.028 |
| Popis: |
Multisystem inflammatory syndrome in children (MIS-C) is a potentially life-threatening sequela of severe acute respiratory syndrome coronavirus 2 infection characterized by hyperinflammation and multiorgan dysfunction. Although hyperinflammation is a prominent manifestation of MIS-C, there is limited understanding of how the inflammatory state of MIS-C differs from that of well-characterized hyperinflammatory syndromes such as hemophagocytic lymphohistiocytosis (HLH).We sought to compare the qualitative and quantitative inflammatory profile differences between patients with MIS-C, coronavirus disease 2019, and HLH.Clinical data abstraction from patient charts, T-cell immunophenotyping, and multiplex cytokine and chemokine profiling were performed for patients with MIS-C, patients with coronavirus disease 2019, and patients with HLH.We found that both patients with MIS-C and patients with HLH showed robust T-cell activation, markers of senescence, and exhaustion along with elevated TOverall, this study characterizes unique and overlapping immunologic features that help to define the hyperinflammation associated with MIS-C versus HLH. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect