Age-related reduction in motor adaptation: brain structural correlates and the role of explicit memory
| Autor: | Noham Wolpe, James N. Ingram, Kamen A. Tsvetanov, Richard N. Henson, Daniel M. Wolpert, James B. Rowe, Lorraine K. Tyler, Carol Brayne, Edward T. Bullmore, Andrew C. Calder, Rhodri Cusack, Tim Dalgleish, John Duncan, Fiona E. Matthews, William D. Marslen-Wilson, Meredith A. Shafto, Karen Campbell, Teresa Cheung, Simon Davis, Linda Geerligs, Rogier Kievit, Anna McCarrey, Abdur Mustafa, Darren Price, David Samu, Jason R. Taylor, Matthias Treder, Janna van Belle, Nitin Williams, Lauren Bates, Tina Emery, Sharon Erzinçlioglu, Andrew Gadie, Sofia Gerbase, Stanimira Georgieva, Claire Hanley, Beth Parkin, David Troy, Tibor Auer, Marta Correia, Lu Gao, Emma Green, Rafael Henriques, Jodie Allen, Gillian Amery, Liana Amunts, Anne Barcroft, Amanda Castle, Cheryl Dias, Jonathan Dowrick, Melissa Fair, Hayley Fisher, Anna Goulding, Adarsh Grewal, Geoff Hale, Andrew Hilton, Frances Johnson, Patricia Johnston, Thea Kavanagh-Williamson, Magdalena Kwasniewska, Alison McMinn, Kim Norman, Jessica Penrose, Fiona Roby, Diane Rowland, John Sargeant, Maggie Squire, Beth Stevens, Aldabra Stoddart, Cheryl Stone, Tracy Thompson, Ozlem Yazlik, Dan Barnes, Marie Dixon, Jaya Hillman, Joanne Mitchell, Laura Villis |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Cerebellum Aging Sensorimotor adaptation Adolescent Explicit memory Movement Population Hippocampus Article Temporal lobe 03 medical and health sciences Young Adult 0302 clinical medicine Cognition Memory Motor control medicine Humans Learning 10. No inequality education Aged Aged 80 and over education.field_of_study General Neuroscience Brain Middle Aged Adaptation Physiological Ageing 030104 developmental biology medicine.anatomical_structure Medial temporal lobe Female Neurology (clinical) Geriatrics and Gerontology Psychology Neuroscience 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Neurobiology of Aging |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2020.02.016 |
| Popis: | The adaption of movement to changes in the environment varies across life span. Recent evidence has linked motor adaptation and its reduction with age to differences in “explicit” learning processes. We examine differences in brain structure and cognition underlying motor adaptation in a population-based cohort (n = 322, aged 18–89 years) using a visuomotor learning task and structural magnetic resonance imaging. Reduced motor adaptation with age was associated with reduced volume in striatum, prefrontal, and sensorimotor cortical regions, but not cerebellum. Medial temporal lobe volume, including the hippocampus, became a stronger determinant of motor adaptation with age. Consistent with the role of the medial temporal lobes, declarative long-term memory showed a similar interaction, whereby memory was more positively correlated with motor adaptation with increasing age. By contrast, visual short-term memory was related to motor adaptation, independently of age. These results support the hypothesis that cerebellar learning is largely unaffected in old age, and the reduction in motor adaptation with age is driven by a decline in explicit memory systems. Highlights • Reduced motor adaptation with age relates to less graey matter in motor regions. • These regions are striatum, premotor and prefrontal cortex, but not the cerebellum. • With age, motor adaptation is more positively related to medial temporal lobe areas. • Motor adaptation relates to short-term memory measures regardless of age. • With age, motor adaptation is more positively related to long-term memory scores. |
| Databáze: | OpenAIRE |
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