Pilot multi-site and reproducibility study of hypothalamic gliosis in children
| Autor: | Susan J. Melhorn, Mary F. Webb, Christian L. Roth, Jun Hua, Ellen A. Schur, Afroditi Papantoni, Susan Carnell, Leticia E. Sewaybricker |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Hypothalamus Hippocampus 030209 endocrinology & metabolism Grey matter Article White matter 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Gliosis Child 030109 nutrition & dietetics Nutrition and Dietetics business.industry Health Policy Putamen Ventral striatum Public Health Environmental and Occupational Health Hypothalamic gliosis Brain Reproducibility of Results Magnetic Resonance Imaging medicine.anatomical_structure Endocrinology Cross-Sectional Studies Pediatrics Perinatology and Child Health Female medicine.symptom business Body mass index |
| Zdroj: | Pediatr Obes |
| ISSN: | 2047-6310 |
| Popis: | OBJECTIVE Quantitative magnetic resonance imaging (MRI) evidence of mediobasal hypothalamic (MBH) gliosis positively correlates with body mass index (BMI) in adults. This has neither been well explored in children nor have other brain regions involved in appetitive processing been tested for evidence of gliosis. METHODS Multi-site cross-sectional study in children to test for differences in quantitative T2 signal (measure of gliosis) by region and to assess relationships with age and BMI. Participants underwent brain MRI using the same equipment and protocol to quantify T2 relaxation time in six bilateral regions of interest (ROIs): putamen, caudate, ventral striatum, amygdala, hippocampus and MBH, and three control regions: white matter, motor cortex and dorsal hypothalamus. RESULTS Thirty-one participants (61% female) were included in a combined sample from the University of Washington (N = 9) and John Hopkins University (N = 22). Mean age was 14 ± 3 years, and BMI z-score was 0.7 ± 1.1 (26% with obesity). No study site-related differences were seen in T2 relaxation time across all nine regions (chi2 (8): 9.46, P = .30). Regional differences in T2 relaxation time were present (P |
| Databáze: | OpenAIRE |
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