Atopic sensitization in the first year of life
| Autor: | Markus J. Ege, Erika von Mutius, Juha Pekkanen, Marjut Roponen, Roger Lauener, Jean-Charles Dalphin, Caroline Roduit, Juliane Weber, Josef Riedler, Charlotte Braun-Fahrländer, Martin Depner, Jon Genuneit, Petra Ina Pfefferle, Maija-Riitta Hirvonen, Susanne Krauss-Etschmann, Vincent Kaulek |
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| Přispěvatelé: | Institute of Epidemiology, Universität Ulm, Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Asthma and Allergy Department, University Children's Hospital-Ludwig Maximilians University, Universität Ulm - Ulm University [Ulm, Allemagne], Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), University of Zurich, Depner, Martin |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Rural Population Pediatrics MESH: Maternal-Fetal Exchange First year of life medicine.disease_cause Immunoglobulin E [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract atopic sensitization early life environmental exposures 0302 clinical medicine Allergen MESH: Pregnancy MESH: Rural Population Pregnancy Surveys and Questionnaires Immunology and Allergy MESH : Female Maternal-Fetal Exchange Sensitization MESH : Allergens 2. Zero hunger 0303 health sciences biology MESH: Immunoglobulin E MESH : Questionnaires MESH : Infant Fetal Blood MESH: Infant 3. Good health Europe medicine.anatomical_structure Cord blood 2723 Immunology and Allergy Female medicine.medical_specialty MESH: Allergens MESH: Hypersensitivity MESH : Male Immunology MESH: Environmental Exposure MESH : Europe Atopic sensitization 610 Medicine & health MESH : Immunoglobulin E [ SDV.EE.SANT ] Life Sciences [q-bio]/Ecology environment/Health 03 medical and health sciences medicine Hypersensitivity Humans MESH: Fetal Blood 030304 developmental biology [SDV.EE.SANT]Life Sciences [q-bio]/Ecology environment/Health MESH : Fetal Blood 2403 Immunology MESH: Humans MESH : Hypersensitivity business.industry MESH: Questionnaires MESH : Humans Infant MESH : Maternal-Fetal Exchange Odds ratio Environmental Exposure Allergens medicine.disease MESH: Male MESH : Rural Population MESH : Pregnancy 030228 respiratory system 10036 Medical Clinic biology.protein MESH: Europe business MESH: Female MESH : Environmental Exposure |
| Zdroj: | Journal of Allergy and Clinical Immunology Journal of Allergy and Clinical Immunology, Elsevier, 2013, 131 (3), pp.781-8. 〈10.1016/j.jaci.2012.11.048〉 Journal of Allergy and Clinical Immunology, Elsevier, 2013, 131 (3), pp.781-8. ⟨10.1016/j.jaci.2012.11.048⟩ J. Allergy Clin. Immunol. 131, 781-788 (2013) |
| ISSN: | 0091-6749 |
| DOI: | 10.1016/j.jaci.2012.11.048〉 |
| Popis: | International audience; BACKGROUND: There is conflicting evidence on whether allergen-specific memory is primed prenatally, whether this priming affects persistent immunologic effects, and whether it is modulated by the first environmental exposures in infancy. OBJECTIVE: We sought to explore the course of atopic sensitization between birth and 12 months of age. METHODS: Specific IgE levels for 6 food and 13 common inhalant allergens were assessed in cord blood and 1-year blood samples in the Protection against Allergy-Study in Rural Environments (PASTURE) birth cohort including 793 children from rural regions of 5 European countries. Detailed information on children's health, nutrition, and farm-related exposures was gathered by using a pregnancy questionnaire, 2 questionnaires at 2 and 12 months of age, and a diary covering the time in between. RESULTS: Sensitization was more common at 12 months of age than at birth for almost all specificities. On an individual level, persistent sensitization to the same allergens was rare (1%), whereas transient (only at birth, 11%) and incident (only at 12 months, 34%) sensitization was seen in substantial proportions of children. Associations of transient sensitization with maternal sensitization differed with the allergen specificities, with the strongest associations for food allergens (odds ratio [OR], 10.6; 95% CI, 6.0-18.6) and the weakest associations for seasonal allergens (OR, 1.64; 95% CI, 0.94-2.86). Associations of maternal sensitization with incident sensitization were also seen. Incident sensitization was related to distinct prenatal and postnatal environmental exposures of mother and child, such as consumption of cereals for incident sensitization to seasonal allergens (OR, 0.66; 95% CI, 0.50-0.88). CONCLUSION: IgE sensitization patterns change between birth and 12 months and are related to maternal and environmental influences. |
| Databáze: | OpenAIRE |
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