Primary Gleason pattern as a predictor of disease progression in gleason score 7 prostate cancer: a multivariate analysis of 823 men treated with radical prostatectomy
| Autor: | Makoto Ohori, Peter T. Scardino, Michael W. Kattan, C. M. Herman, Thomas M. Wheeler |
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| Rok vydání: | 2001 |
| Předmět: |
Oncology
Male medicine.medical_specialty Surgical margin Pathology Multivariate analysis medicine.medical_treatment Adenocarcinoma Pathology and Forensic Medicine Prostate cancer Prostate Internal medicine medicine Humans Neoplasm Invasiveness Prostatectomy business.industry Prostatic Neoplasms medicine.disease Survival Rate medicine.anatomical_structure Lymphatic Metastasis Multivariate Analysis Disease Progression Surgery Lymph Nodes Anatomy Neoplasm Recurrence Local business Primary Gleason Pattern Radical retropubic prostatectomy |
| Zdroj: | The American journal of surgical pathology. 25(5) |
| ISSN: | 0147-5185 |
| Popis: | Gleason score (GS) is a powerful predictor of disease progression in men with prostate cancer (PCa). The majority of clinically localized prostate cancers, however, are moderately (GS5/6) or moderate to poorly (GS7) differentiated tumors with indeterminate prognosis. Differences in disease progression between patients with GS5/6 and GS7 tumors suggest the presence of any component of high-grade tumor (Gleason pattern [GP] 4/5) worsens prognosis markedly. Indeed, McNeal et al. have shown that quantification of GP4/5 provides prognostic information beyond the standard GS. Few investigators have analyzed whether primary and secondary GPs are important prognostically within GS7 PCa. All 823 whole-mount radical prostatectomy specimens with GS7 from a single surgeon (P.T.S.) were analyzed. Tumors were either 3+4 or 4+3, and primary GP was assigned by the same pathologist (T.M.W.). A total of 643 patients with 3+4 tumors and 180 patients with 4+3 tumors were studied. Statistical analysis using the log-rank test showed a significant difference in recurrence-free survival between patients with primary GP4 and those with GP3 (p |
| Databáze: | OpenAIRE |
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