Face shape of unaffected parents with cleft affected offspring: combining three-dimensional surface imaging and geometric morphometrics
| Autor: | Rick A. Martin, M. L. Marazita, K Neiswanger, Sybill D. Naidoo, JM Resick, Seth M. Weinberg, CA Brandon, K. M. Bardi |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Parents Cephalometry Cleft Lip Population Orthodontics Nose Biology Article Face shape Imaging Three-Dimensional Sex Factors Midface retrusion Humans Genetic Predisposition to Disease Family history Maxillofacial Development education Family Health Morphometrics Principal Component Analysis Zygoma education.field_of_study Statistical shape analysis Vertical Dimension Anatomy Craniometry Lip Cleft Palate Otorhinolaryngology Case-Control Studies Face Photogrammetry Female Surgery Oral Surgery Procrustes analysis Orbit |
| Zdroj: | Orthodontics & Craniofacial Research. 12:271-281 |
| ISSN: | 1601-6343 1601-6335 |
| Popis: | Structured Abstract Authors – Weinberg SM, Naidoo SD, Bardi KM, Brandon CA, Neiswanger K, Resick JM, Martin RA, Marazita ML Objective – Various lines of evidence suggest that face shape may be a predisposing factor for non-syndromic cleft lip with or without cleft palate (CL/P). In the present study, 3D surface imaging and statistical shape analysis were used to evaluate face shape differences between the unaffected (non-cleft) parents of individuals with CL / P and unrelated controls. Methods – Sixteen facial landmarks were collected from 3D captures of 80 unaffected parents and 80 matched controls. Prior to analysis, each unaffected parent was assigned to a subgroup on the basis of prior family history (positive or negative). A geometric morphometric approach was utilized to scale and superimpose the landmark coordinate data (Procrustes analysis), test for omnibus group differences in face shape, and uncover specific modes of shape variation capable of discriminating unaffected parents from controls. Results – Significant disparity in face shape was observed between unaffected parents and controls (p |
| Databáze: | OpenAIRE |
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