Atypical glandular cells and adenocarcinoma in situ according to the Bethesda 2001 classification: Cytohistological correlation and clinical implications
| Autor: | Luis Otávio Sarian, Luiz Carlos Zeferino, Eliane Regina Zambelli Mesquita de Oliveira, L. A. L. Angelo-Andrade, Maria Cristina do Amaral Westin, Sophie Françoise Mauricette Derchain, Silvia Helena Rabelo-Santos |
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| Rok vydání: | 2008 |
| Předmět: |
Vaginal Smears
Pathology medicine.medical_specialty medicine.diagnostic_test business.industry Bethesda system Not Otherwise Specified Uterine Cervical Neoplasms Obstetrics and Gynecology Adenocarcinoma Uterine Cervical Dysplasia medicine.disease Cervical intraepithelial neoplasia Squamous carcinoma stomatognathic diseases Squamous intraepithelial lesion Reproductive Medicine Epidermoid carcinoma Carcinoma Squamous Cell medicine Carcinoma Humans Female business |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 139:79-85 |
| ISSN: | 0301-2115 |
| DOI: | 10.1016/j.ejogrb.2007.08.017 |
| Popis: | Background The objective of this study was to evaluate the correlation between the 2001 Bethesda classification of endocervical glandular abnormalities and histological diagnosis. Study design A series of 155 women with endocervical glandular abnormalities on cervical smears were included: 91 with atypical glandular cells (AGC) not otherwise specified (NOS), 15 with AGC-favor neoplastic (FN); 35 with AGC associated with high-grade squamous intraepithelial lesion (HSIL) as combined diagnosis and 14 with adenocarcinoma in situ (AIS). Results Histological outcome of squamous neoplasias (CIN 2 or worse) and adenocarcinoma were significantly associated with AGC-FN and AIS, taking as reference AGC-NOS, and more associated with AIS than AGC-FN. Similar associations were observed for histological outcome of adenocarcinoma, but no association was observed for only squamous neoplasia. Histological outcome of CIN2 or worse was strongly associated with AGC when HSIL was also present, but no association was observed with only for adenocarcinoma histological outcome. Conclusions AGC-NOS, AGC-FN and AIS cytological diagnosis represent a progressively increasing association with neoplastic diagnosis, due to progressively increasing association with adenocarcinoma. Histological outcome of squamous neoplasia is frequent but does not differ with these cytological interpretations. The presence of HSIL associated with AGC represents greater probability of squamous neoplasia but not adenocarcinoma. |
| Databáze: | OpenAIRE |
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