Breast Cancer Risk and Follow-up Recommendations for Young Women Diagnosed with Atypical Hyperplasia and Lobular Carcinoma In Situ (LCIS)
| Autor: | Constance A. Roche, Michele A. Gadd, Keven S. Hughes, Ahmet Korkut Belli, Anthony J. Guidi, Rong Tang, Andrea L. Merrill, Emanuele Mazzola, Suzanne B. Coopey, Michelle C. Specht, Judy Garber, Maureen P. McEvoy, Barbara L. Smith, Julliette M. Buckley, Fernanda Polubriaginof |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Population Breast Neoplasms Atypical hyperplasia Young Adult Breast cancer Risk Factors Internal medicine Lobular carcinoma in situ (LCIS) medicine Humans Neoplasm Invasiveness Breast Young adult skin and connective tissue diseases education Early Detection of Cancer Neoplasm Staging Retrospective Studies education.field_of_study Hyperplasia business.industry Carcinoma in situ Carcinoma Ductal Breast Cancer Retrospective cohort study Continuity of Patient Care Prognosis medicine.disease Carcinoma Lobular Female Surgery business Precancerous Conditions Carcinoma in Situ Follow-Up Studies Mammography |
| Zdroj: | Annals of Surgical Oncology. 22:3346-3349 |
| ISSN: | 1534-4681 1068-9265 |
| DOI: | 10.1245/s10434-015-4747-1 |
| Popis: | The risk of breast cancer in young women diagnosed with atypical hyperplasia and (LCIS) is not well defined. The objectives were to evaluate outcomes and to help determine guidelines for follow-up in this population. A retrospective review of women under age 35 diagnosed with ADH, ALH, LCIS, and severe ADH from 1987 to 2010 was performed. Patient characteristics, pathology and follow-up were determined from chart review. We identified 58 young women with atypical breast lesions. Median age at diagnosis was 31 years (range 19–34). 34 patients had ADH, 11 had ALH, 8 had LCIS, and 5 had severe ADH. 7 (12%) patients developed breast cancer. The median follow-up was 86 months (range 1–298). Median time to cancer diagnosis was 90 months (range 37–231). 4 cancers were on the same side, 3 were contralateral. 4 were IDC, 1 was ILC, and 2 were DCIS. Cancer was detected by screening mammogram in 4 patients, 2 by clinical exam, and 1 unknown. In the entire cohort, 26 (45%) patients had screening mammograms as part of their follow up, 12 patients had only clinical follow up, and 20 had no additional follow up. 13 patients required subsequent biopsies. Young women with atypical breast lesions are at a markedly increased risk for developing breast cancer and should be followed closely. Based on our findings, we recommend close clinical follow-up, MRI starting at age 25 through age 29, and screening mammograms for those over 30 in this high-risk group of patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink