A monoclonal antibody distinguishes two types of phosphatidylinositol 4-kinase
| Autor: | Endemann G, Lewis C. Cantley, Andrea Graziani |
|---|---|
| Přispěvatelé: | Endemann, Graziani, Andrea, Cantley |
| Rok vydání: | 1991 |
| Předmět: |
Erythrocytes
Immunoprecipitation medicine.drug_class Monoclonal antibody Biochemistry Isozyme Xenopus laevis chemistry.chemical_compound medicine Animals Humans Phosphatidylinositol 1-Phosphatidylinositol 4-Kinase Molecular Biology Gene Ovum chemistry.chemical_classification biology Kinase Phosphotransferases Antibodies Monoclonal Brain Cell Biology Molecular biology Rats Enzyme Liver chemistry biology.protein Cattle Antibody Research Article |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1470-8728 0264-6021 |
| DOI: | 10.1042/bj2730063 |
| Popis: | A monoclonal antibody has been developed against the type II PtdIns 4-kinase from bovine brain. This antibody, 4C5G, causes greater than 90% inhibition of the type II PtdIns 4-kinase from bovine brain, rat brain and human erythrocytes. However, it fails to inhibit type III PtdIns 4-kinase from bovine brain or PtdIns 3-kinase from rat liver. These results suggest that type II and type III PtdIns 4-kinases are distinct gene products, and that 4C5G will be useful in studying the function of the type II PtdIns 4-kinase. |
| Databáze: | OpenAIRE |
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