Associations between the FKBP5 haplotype, exposure to violence and anxiety in females
| Autor: | Cecilia Åslund, Johan Isaksson, Henrik Andershed, Kent W. Nilsson, Catherine Tuvblad, Mattias Rehn, Erika Comasco |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Poison control Anxiety Polymorphism Single Nucleotide Tacrolimus Binding Proteins 03 medical and health sciences Young Adult 0302 clinical medicine Endocrinology Sex Factors Injury prevention medicine Genetic predisposition Humans Young adult Psychiatry Biological Psychiatry Depression (differential diagnoses) Exposure to Violence Endocrine and Autonomic Systems Depression Haplotype 030227 psychiatry Psychiatry and Mental health Haplotypes Female FKBP5 medicine.symptom Psychology 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Psychoneuroendocrinology. 72 |
| ISSN: | 1873-3360 |
| Popis: | The gene that encodes the FK506-binding protein 5 (FKBP5) is regarded as a candidate for investigating how negative life events interact with a genetic predisposition to stress-related disorders, such as depression and anxiety. Given the role of FKBP5 as an important regulator of stress responses, we aimed to investigate if single-nucleotide polymorphisms (SNPs) in FKBP5-in the presence/absence of exposure to violence-are associated with symptoms of depression and anxiety. Data from two community-based samples of adolescents (n=1705) and young adults (n=1800) regarding ratings on depression, anxiety, exposure to violence and FKBP5 genotype were collected. A risk haplogenotype including the minor alleles of seven common SNPs in the FKBP5 (rs3800373, rs9296158, rs7748266, rs1360780, rs9394309, rs9470080 and rs4713916) conferred higher ratings on anxiety among females, but not males, in the presence of violence. Exposure to violence and female sex were associated with higher ratings on both depression and anxiety, with the exception of ratings on depression among young adults, on which sex had no effect. Ratings on depression were not associated with the haplogenotype. These findings may correspond to differences in the regulation of the HPA axis and with the higher vulnerability to anxiety in females. |
| Databáze: | OpenAIRE |
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