| Autor: |
Leaf Huang, William Y. Kim, Shihao Hu, Weiyan Yin, Lina Liu, Yuhua Wang, Cong Luo, C. Michael Lin, Qi Liu, Lei Miao |
| Rok vydání: |
2023 |
| Popis: |
Supplementary Table S1. Antibodies Used in the Study Supplementary Table S2. Characterization of LPD NPs Supplementary Table S3. Primers Used in the Study Supplementary Table S4. Blood Chemistry after Treatments Supplementary Figure S1. Morphology and in vivo biodistribution of LPD NPs. Supplementary Figure S2. Histology (H&E, left; IF, right; adjacent sections) of mice bearing UMUC3/3T3 tumors. Supplementary Figure S3. Calculation of DiI positive cells in each cell population within UMUC/3T3 xenograft tumors by flow cytometry (n=4). Supplementary Figure S4. In vitro transfection efficiency of sTRAIL or TRAIL loaded LPD on UMUC3 bladder cancer cell line. Supplementary Figure S5. Neighboring tumor-suppressive effect of the secreted TRAIL protein. Supplementary Figure S6. qPCR quantitation of relative mRNA levels of sTRAIL in the UMUC3/3T3 tumors after different treatments. Supplementary Figure S7. ELISA quantification of the expression and secretion of sTRAIL protein in the UMUC3/3T3 tumors after different treatments. Supplementary Figure S8. Collagen remodeling during the dose escalation of sTRAIL LPD. Supplementary Figure S9. Remodeling of tumor microenvironment after sTRAIL LPD treatment. Supplementary Figure S10. Histology (both fibroblast staining and collagen staining) of orthotopic BXPC3-Luc2 mouse xenograft. Supplementary Figure S11. sTRAIL LPD inhibited the metastasis of BXPC3-Luc2 tumors Supplementary Figure S12. Expression of GFP within different cell populations of BXPC3-Luc2 tumors after 3 doses of sTRAIL or TRAIL NPs (co-expressing GFP). Supplementary Figure S13. Collagen staining of tumors from mice treated with PBS and sTRAIL LPD NP, respectively. Supplementary Figure S14. In vivo cytotoxicity evaluation and organ distribution of sTRAIL or TRAIL LPD. Supplementary Figure S15. Apoptosis of neighboring tumor cells reduces the activation of fibroblasts. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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