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Miftah Mohammed,1 Mesfin Fiseha,1 Getachew Belay,2 Samuel Kindie,3 Aster Tsegaye3 1Department of Medical Laboratory Science, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia; 2Department of Medical laboratory science, College of Health Sciences, Adigrat University, Adigrat, Ethiopia; 3Department of Medical Laboratory Science, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Miftah Mohammed, Email amarmiftah100@gmail.comAbstract: Background: Physiological changes during pregnancy cause alterations in concentration of biochemical analytes. Thus, locally established pregnancy-specific reference intervals are important for accurate diagnosis, treatment, and prognosis of diseases. The objective of the study was to establish reference interval for the common renal and liver function clinical chemistry parameters among pregnant and non-pregnant women of South Wollo zone, Ethiopia.Methods: A community-based cross-sectional study was conducted on a total of 323 apparently healthy study participants randomly selected from South Wollo zone, Ethiopia, from April to June 2019. Medical history, physical examination and sociodemography were collected by using questionnaire. Liver and renal function clinical chemistry tests were done using A25 Biosystems, clinical chemistry analyzer. After the exclusion of outliers, KolmogorovâSmirnov test was used to check its normality. The 95% RI with 95% confidence interval was established using the nonparametric method. The significance of differences was evaluated using MannâWhitney U test.Result: There was statistically significant variation between pregnant and non-pregnant women in values of albumin, T. protein, ALP, urea and creatinine, but not for AST, ALT, bilirubin (direct) and bilirubin (total). Reference intervals established for pregnant women includes albumin 26.14â 42.87g/L, total protein 48.52â 74.71 g/L, AST 2.4â 43.6 U/L, ALT 0.94â 28.35 U/L, ALP 21.2â 337 U/L, bilirubin (direct) 0.03â 0.32 mg/dL, bilirubin (total) 0.26â 0.94 mg/dL, creatinine 0.29â 0.87 mg/dL, urea 7.17â 20.82 mg/dL. Albumin: 32.81â 47.87, total protein: 56.71â 83.9 U/L, AST: 4.2â 37.1 U/L, ALT: 2.69â 41.18 U/L, ALP: 3.22â 278.7 U/L, bilirubin (direct) 0.1â 0.51 mg/dL, bilirubin (total) 0.24â 1.06 mg/dL, creatinine 0.44â 1.00 mg/dL, urea 8.07â 27.87 mg/dL for non-pregnant women.Conclusion: The study showed marked difference in albumin, total protein, alkaline phosphatase, urea and creatinine. Therefore, physiological adaptations of pregnancy should be considered when interpreting liver and renal function tests in a pregnant woman.Keywords: reference interval, clinical chemistry, pregnant, non-pregnant |
