Function of the Eustachian Tube After Weekly Exposure to Pepsin/Hydrochloric Acid
| Autor: | Jiri Prazma, David R. White, Harold C. Pillsbury, S. Brett Heavner, Chapman T. McQueen, Stuart M. Hardy |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Eustachian tube
Hydrochloric acid Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Gastrointestinal Agents Pepsin Pressure medicine Animals 030223 otorhinolaryngology biology Otitis Media with Effusion business.industry Eustachian Tube Phosphate buffered saline Head neck Reflux Pepsin A Rats Sprague dawley medicine.anatomical_structure Otorhinolaryngology chemistry 030220 oncology & carcinogenesis Anesthesia Models Animal Gastroesophageal Reflux Middle ear biology.protein Surgery Hydrochloric Acid business |
| Zdroj: | Otolaryngology–Head and Neck Surgery. 125:123-129 |
| ISSN: | 1097-6817 0194-5998 |
| DOI: | 10.1067/mhn.2001.116448 |
| Popis: | Objective: To determine the effects of repeated pepsin/hydrochloric acid (HCl) exposure on the eustachian tube (ET). Study Design and Setting: ET function was studied in 22 rats. Group I (control) rats received transtympanic phosphate buffered saline solution; groups II (0.5 mg/ml) and III (2.0 mg/ml) received transtympanic pepsin/HCl. Test solutions were applied on day 0 with ET function evaluated on days 1, 2, 3, and 7 after exposure. Each 7-day period represents 1 cycle; all groups underwent 4 cycles. ET function was evaluated using passive opening and closing pressure, and active clearance of positive and negative pressure tests. Results: Rats exposed to pepsin/HCl had elevated passive opening pressures and a decreased ability to clear positive and negative pressure. A temporal relationship exists. Conclusion: The results suggest middle ear exposure to pepsin/HCl leads to ET dysfunction in rats, and that this dysfunction is enhanced with repeated exposures. Significance: Gastroesophageal reflux may induce ET dysfunction. (Otolaryngol Head Neck Surg 2001;125:123-9.) |
| Databáze: | OpenAIRE |
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