The Role of the Level of Interleukin-33 in the Therapeutic Outcomes of Immunotherapy in Patients with Allergic Rhinitis
| Autor: | Wail Fayez Nasr, Ghada Samir Boghdadi, Atef Taha El Bahrawy, Samir Sorour Sorour, Alia A El Shahaway |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Allergen immunotherapy medicine.medical_treatment Population lcsh:Medicine Immunoglobulin E Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine In patient education Original Research education.field_of_study rhinorrhea allergic rhinitis biology helper T cells business.industry lcsh:R Interleukin Immunotherapy lcsh:Otorhinolaryngology lcsh:RF1-547 Interleukin 33 030104 developmental biology 030228 respiratory system Otorhinolaryngology Immunology biology.protein allergen immunotherapy immunotherapy medicine.symptom business |
| Zdroj: | International Archives of Otorhinolaryngology International Archives of Otorhinolaryngology, Vol 22, Iss 02, Pp 152-156 (2018) International Archives of Otorhinolaryngology, Volume: 22, Issue: 2, Pages: 152-156, Published: JUN 2018 International Archives of Otorhinolaryngology v.22 n.2 2018 Fundação Otorrinolaringologia (FORL) instacron:FORL |
| ISSN: | 1809-9777 |
| Popis: | Introduction Allergic rhinitis (AR) affects up to 40% of the population and results in nasal itching, congestion, sneezing, and clear rhinorrhea. Objectives This study aimed to evaluate the changes in the clinical symptoms and in the level of serum interleukin (IL)-33 before and after pollen immunotherapy (IT) in patients with AR. Methods The total symptom score and the levels of total immunoglobulin E (IgE) and IL-33 were determined in the serum of 10 non-allergic healthy controls and 45 patients with AR who were equally divided into 3 groups: GI (patients did not receive IT), GII (patients had received IT for 6 months) and GIII (patients had received IT for 2 years). Results There was a significantly higher concentration of IgE and IL-33 in the serum of patients with AR than in that of non-allergic patients. Furthermore, serum level of IL-33 decreased significantly after pollen IT. But, there was no significant reduction in the serum level of IL-33 between GII and GIII patients. Conclusion Our results show a clinical improvement associated with a decrease in serum level of IL-33 after pollen IT. |
| Databáze: | OpenAIRE |
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