Efficacy of Prucalopride for Chronic Idiopathic Constipation: An Analysis of Participants With Moderate to Very Severe Abdominal Bloating
| Autor: | William Spalding, Kyle Staller, Jimmy Hinson, Rene Kerstens, Anthony Lembo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Abdominal bloating Placebo Brief Communication Gastroenterology Severity of Illness Index Chronic idiopathic constipation Bloating Double-Blind Method Internal medicine Post-hoc analysis medicine Humans Functional GI Disorders Aged Benzofurans Pain Measurement Prucalopride Hepatology business.industry digestive oral and skin physiology digestive system diseases humanities Abdominal Pain Treatment Outcome Laxatives Chronic Disease Population study Female business Constipation medicine.drug |
| Zdroj: | The American Journal of Gastroenterology |
| ISSN: | 1572-0241 0002-9270 |
| Popis: | INTRODUCTION: This post hoc analysis evaluated the effect of prucalopride on abdominal bloating in participants with chronic idiopathic constipation (CIC) who had moderate to very severe bloating at baseline. Methods: Data from 6 phase 3/4 studies of prucalopride in participants with CIC were pooled. Abdominal bloating was assessed weekly using a 5-point scale (0–4). Results: The proportion of bloating responders (≥1-point improvement in abdominal bloating score at week 12) was higher in participants treated with prucalopride (62.1%) vs placebo (49.6%). DISCUSSION: The prucalopride arm had a higher proportion of bloating responders vs placebo in this study population. |
| Databáze: | OpenAIRE |
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