Corrected QT Variability in Serial Electrocardiograms in Long QT Syndrome
| Autor: | Mark L. Andrews, Jennifer L. Robinson, Wojciech Zareba, Arthur J. Moss, Derick R. Peterson, G. Michael Vincent, Scott McNitt, Brian Morray, Li Zhang, Jesaia Benhorin, Jehu Mathew, Ilan Goldenberg |
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| Rok vydání: | 2006 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities medicine.medical_specialty medicine.diagnostic_test Heart disease Heart block business.industry Long QT syndrome Hazard ratio Corrected qt medicine.disease QT interval Internal medicine cardiovascular system medicine Cardiology cardiovascular diseases Cardiology and Cardiovascular Medicine business Risk assessment Electrocardiography circulatory and respiratory physiology |
| Zdroj: | Journal of the American College of Cardiology. 48:1047-1052 |
| ISSN: | 0735-1097 |
| Popis: | Objectives We evaluated the incremental prognostic information provided by multiple corrected QT (QTc) measurements on serial electrocardiograms (ECGs) in patients with the inherited long QT syndrome (LQTS). Background A baseline QTc of ≥500 ms has been shown to be associated with increased risk of cardiac events among LQTS patients. However, the value of QTc measurements on follow-up ECGs in risk assessment has not been determined. Methods The risk of a first LQTS-related cardiac event during adolescence was assessed in 375 patients enrolled in the International LQTS Registry for whom serial follow-up ECGs were recorded before age 10. Results The mean ± SD difference between the minimum and maximum QTc values on serial ECGs recorded in study patients was 47 ± 40 ms. The maximum QTc interval recorded before age 10 was the strongest predictor of cardiac events during adolescence (adjusted hazard ratio [HR] = 2.74; p Conclusions In LQTS patients, there is a considerable variability in QTc measures in serial follow-up ECGs. The maximum QTc interval provides incremental prognostic information beyond the baseline measurement. We suggest that risk stratification in LQTS patients should include follow-up ECG data. |
| Databáze: | OpenAIRE |
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