Seasonal variations of 25-OH vitamin D serum levels are associated with clinical disease activity in multiple sclerosis patients
| Autor: | Viola Obermeier, Tania Kümpfel, Rüdiger von Kries, Lisa Ann Gerdes, Christina Hartl, Mathias Brügel |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Multiple Sclerosis Future studies Adolescent Gastroenterology Disease activity Young Adult 03 medical and health sciences 0302 clinical medicine Recurrence Internal medicine medicine Vitamin D and neurology Humans Vitamin D Chromatography High Pressure Liquid Aged Expanded Disability Status Scale Vitamin d supplementation business.industry Multiple sclerosis Middle Aged Serum concentration medicine.disease Clinical disease 030104 developmental biology Endocrinology Neurology Female Seasons Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Journal of the Neurological Sciences. 375:160-164 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/j.jns.2017.01.059 |
| Popis: | Low 25-hydroxy vitamin D (25-[OH]-D) serum concentrations have been associated with higher disease activity in multiple sclerosis (MS) patients. In a large cross-sectional study we assessed the vitamin D status in MS patients in relation to seasonality and relapse rate. 415 MS-patients (355 relapsing-remitting MS and 60 secondary-progressive, 282 female, mean age 39.1years) of whom 25-(OH)-D serum concentrations were determined at visits between 2010 and 2013 were included in the study. All clinical data including relapse at visit and expanded disability status scale were recorded in a standardized manner by an experienced neurologist. Seasonal variations of 25-(OH)-D serum concentrations were modelled by sinusoidal regression and seasonal variability in the prevalence of relapse by cubic regression. The mean 25-(OH)-D serum concentration was 24.8ng/ml (range 8.3-140ng/ml) with peak levels of 32.2ng/ml in July/August and nadir in January/February (17.2ng/ml). The lowest modelled prevalence of relapse was in September/October (28%) and the highest modelled prevalence in March/April (47%). The nadir of 25-(OH)-D serum concentrations preceded the peak in prevalence of relapses by two months. In summary, seasonal variation of 25-(OH)-D serum levels were inversely associated with clinical disease activity in MS patients. Future studies should investigate whether vitamin D supplementation in MS patients may decrease the seasonal risk for MS relapses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect