HORMONES OF THE ADRENAL CORTEX
| Autor: | Edward C. Kendall |
|---|---|
| Rok vydání: | 1942 |
| Předmět: | |
| Zdroj: | Endocrinology. 30:853-860 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-30-6-853 |
| Popis: | THE ESSENTIAL CONTRIBUTION which subsequently led to the elucidation of the I chemical nature of the hormones of the adrenal cortex was the use of organic solvents for the extraction of the active material from epinephrine and toxic substances which are associated with the hormones in the gland (i, a). By this procedure extracts more or less potent have been made available since 1930, and it has now been shown that patients with Addison's disease and adrenalectomized animals can be protected by an extract of the adrenal cortex against the fatal consequences which are associated with a deficiency of this essential gland. Although this achievement, which indicates that the activity of the adrenal cortex can be substituted by the extract, is satisfactory and under certain conditions highly dramatic, there are many uestions which arise in regard to the nature of the extract. During the past twelve years definite |
| Databáze: | OpenAIRE |
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