Rh-incompatible hemolytic disease of the newborn in Hefei
| Autor: | Chao Zhu, Yong-Li Zhang, Ru-Jeng Teng, Jian Zhang, Chao Wang, Shao-Hua Bi, Juan Wang, Hong Zheng, Li-Ying Dai, Yu Liu, Qiao Jiang, Liang-Liang Jiang, Li-Li Wang, Guang-Hui Liu |
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| Rok vydání: | 2019 |
| Předmět: |
Pediatrics
medicine.medical_specialty 03 medical and health sciences 0302 clinical medicine Retrospective Study Hemolytic disease of the newborn (ABO) Medicine Rh-isoimmunization Rh Isoimmunization Caucasian population biology business.industry General Medicine Jaundice medicine.disease 030220 oncology & carcinogenesis Relative risk Hemolytic disease of the newborn Etiology biology.protein Minor blood group 030211 gastroenterology & hepatology Antibody medicine.symptom business Population policy |
| Zdroj: | World Journal of Clinical Cases |
| ISSN: | 2307-8960 |
| DOI: | 10.12998/wjcc.v7.i20.3202 |
| Popis: | Background Anti-D antibody is not the common cause of Rh-isoimmunization in Chinese neonatal jaundice. Recent change in national population policy has followed by an increase in Rh-isoimmunization related hemolytic disease of the newborn (HDN). Unfortunately, regional status of Rh-HDN is unavailable. We hypothesize that Rh-HDN in our region is most commonly due to anti-E antibody. Aim To investigate the prevalence of hemolytic disease of the newborn due to Rh-isoimmunization in Hefei City. Methods Retrospective review of data obtained from Children's Hospital of Anhui and Hefei Blood Center between January 2017 and June 2019. Status of minor blood group antibody was studied in the corresponding mothers. Results Totally 4138 newborns with HDN admitted during the study period and 116 (2.8%) received blood exchange transfusion (BET). Eighteen newborns (0.43%) with proven Rh-incompatible HDN were identified. All were not the first-born baby. Thirteen mothers were RhD (+) (72%) and five were RhD (-). The distribution of Rh-related antibodies in mothers was ten anti-E (55%), five anti-D (27%), and for one anti-C, anti-c, and anti-E/c (6%) each. Thirteen (72.2%) were qualified for BET, relative risk for BET was 28.9 as compared to other types of HDN, but only 10 received due to parenteral refusal. All (100%) RhD related HDN received BET which is not significantly different from RhE related HDN (81.8%). Conclusion As expected, all Rh-incompatible HDN newborns were not the first-born. Contrary to the Caucasian population, anti-D induced HDN is not the most common etiology. In our region, anti-E (11/18, 61%) is the most common cause of Rh-HDN. |
| Databáze: | OpenAIRE |
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