Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis
| Autor: | Rafael Gonçalves Teixeira Neto, Rodolfo Cordeiro Giunchetti, Lutiana Amaral de Melo, Cláudia Martins Carneiro, Ricardo Wagner de Almeida Vitor, Wendel Coura-Vital, Célia Maria Ferreira Gontijo, Patrícia Flávia Quaresma, Henrique Gama Ker, Alexandre Barbosa Reis |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Antibody Affinity Antibodies Protozoan Biology Parasite load Dogs Canine leishmaniasis medicine Parasite hosting Animals Avidity Dog Diseases Leishmaniasis Skin Leishmania General Veterinary General Medicine Leishmania chagasi medicine.disease biology.organism_classification Visceral leishmaniasis Immunoglobulin G Immunology Parasitology Female Leishmania infantum Spleen |
| Zdroj: | Veterinary parasitology. 169(3-4) |
| ISSN: | 1873-2550 |
| Popis: | The clinical status and tissue parasite burden of the skin and spleen of 40 dogs naturally infected with Leishmania chagasi (syn. Leishmania infantum), together with 5 uninfected control dogs, were assessed. On the basis of the clinical evaluation, infected dogs were classified as asymptomatic (AD) or symptomatic (SD). Infected animals were also grouped according to their parasite load as exhibiting low (LP), medium (MP) and high (HP) parasitism. The results indicated a high parasite load in the skin samples of SD animals in relation to the AD group. The serum immunoglobin isotype profiles of the studied animals revealed increased levels of IgG(1) in the AD and LP dogs, whereas high levels of IgG(2) were correlated with SD and HP dogs. The avidity index (AI) of IgG(total) in the SD group was high in comparison of that of the AD group. Moreover, animals with a larger parasite burden either in the spleen or skin showed higher AI values than animals with lower parasitism. Based on these findings, it is suggested that CVL commences with an asymptomatic clinical form with low parasitism, high production of IgG(1) and low affinity of IgG(total) molecules, and evolves into a symptomatic clinical form with higher parasitism intensity, higher IgG(2) levels, and high affinity of IgG(total). |
| Databáze: | OpenAIRE |
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