Effects of Intranasal Oxytocin on Stress-Induced Cigarette Craving in Daily Smokers
| Autor: | Harriet de Wit, Anya K. Bershad, Kathryne Van Hedger, Royce Lee |
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| Rok vydání: | 2018 |
| Předmět: |
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Original Investigations Craving Placebo behavioral disciplines and activities 01 natural sciences law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Medicine 030212 general & internal medicine 0101 mathematics Hydrocortisone media_common business.industry Addiction 010102 general mathematics Public Health Environmental and Occupational Health Abstinence Oxytocin Anxiety medicine.symptom business psychological phenomena and processes medicine.drug Clinical psychology |
| Zdroj: | Nicotine Tob Res |
| ISSN: | 1469-994X 1462-2203 |
| DOI: | 10.1093/ntr/nty159 |
| Popis: | Background Cigarette smoking is a well-known public health concern, and there is an urgent need to develop new treatments to reduce smoking or facilitate abstinence. One factor that is known to contribute to relapse is stress, making the stress response an important target for treatment. The neuropeptide oxytocin (OT) is believed to have stress-reducing effects, and in addition there is evidence that it reduces drug craving. The purpose of the present study was to examine the effects of intranasal OT on stress-induced cigarette craving in regular smokers after 12 h of abstinence. Method Daily smokers (n = 48) completed a stress induction task and a nonstressful control task at two different sessions, receiving intranasal OT (40 IU) or placebo (PBO) before or after the task. Subjects were randomly assigned to one of three groups: Group PP (n = 16) received PBO before and after the stress/control tasks, Group OP (n = 16) received OT before the tasks and PBO after, and Group PO (n = 16) received PBO before the tasks and OT shortly after completing the tasks. Cigarette craving as well as subjective and physiological responses to stress was assessed. Results OT did not alter responses to stress, whether it was administered before or after the stressful task, on measures of cigarette craving, anxiety, heart rate, blood pressure, and cortisol levels. Conclusions The current study findings do not support several previous reports that OT reduced either stress or drug craving. Implications This study finds a null result of the neuropeptide oxytocin on stress-induced cigarette craving. Reporting null findings is part of the process of identifying potential treatments for addictive disorders. |
| Databáze: | OpenAIRE |
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