Effect of Lithium Treatments on the Tyrosine-Aminopeptidase Activities in the Rat Brain and the Pituitary Gland
| Autor: | J. M. De Gandarias, Javier Gil, David Fernandez, Adolfo Varona, Luis Casis, J. Irazusta Astiazaran |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Pituitary gland medicine.medical_specialty Lithium (medication) Nerve Tissue Proteins Lithium Biology Aminopeptidases Aminopeptidase Rats Sprague-Dawley chemistry.chemical_compound Neurochemical Internal medicine Drug Discovery medicine Animals Tyrosine Protein Synthesis Inhibitors Neurotransmitter Agents Membranes Lithium carbonate Brain Enkephalins Rats Spectrometry Fluorescence medicine.anatomical_structure Endocrinology chemistry Mechanism of action Puromycin Pituitary Gland medicine.symptom medicine.drug |
| Zdroj: | Arzneimittelforschung. 49:816-819 |
| ISSN: | 1616-7066 0004-4172 |
| DOI: | 10.1055/s-0031-1300507 |
| Popis: | Lithium (CAS 7439-93-2) is being utilized widely for the treatment of manic-depressive illness. However, the neurochemical mechanism of the ion action still remains relatively obscure. In the present work, the effect of acute lithium administration on soluble and membrane-bound enkephalin-degrading tyrosine-aminopeptidase activities in discrete brain areas and the pituitary gland is described. Tyrosine-aminopeptidase activities have been measured fluorometrically using Tyr-beta-naphthylamide as substrate and puromycin as selective inhibitor of one of the two membrane activities. Soluble and membrane-bound puromycin-insensitive Tyr-aminopeptidase activities are greater in the pituitary gland after treatment with 5 and 10 meq/kg of lithium. It is suggested that these enzyme activities could play a part in the lithium action mechanism. |
| Databáze: | OpenAIRE |
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