Upregulated expression of N-syndecan, a transmembrane heparan sulfate proteoglycan, in differentiated neural stem cells
| Autor: | Noriaki Kido, Yoshihito Honda, Masaru Inatani, Masatoshi Haruta, Hidenobu Tanihara, Masayo Takahashi, Megumi Honjo, Atsuhiko Oohira |
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| Rok vydání: | 2001 |
| Předmět: |
Cellular differentiation
Immunoblotting Nerve Tissue Proteins Tretinoin Neurosphere Animals RNA Messenger Molecular Biology Neurons Membrane Glycoproteins biology Reverse Transcriptase Polymerase Chain Reaction Stem Cells General Neuroscience Cell Differentiation Immunohistochemistry Neural stem cell Rats Up-Regulation Cell biology carbohydrates (lipids) Neuroepithelial cell Endothelial stem cell Proteoglycan Biochemistry biology.protein Syndecan-3 Proteoglycans Neurology (clinical) Stem cell Developmental Biology Adult stem cell |
| Zdroj: | Brain Research. 920:217-221 |
| ISSN: | 0006-8993 |
| Popis: | Adult rat hippocampus-derived neural stem cells are incorporated into neural tissues, and differentiate to neuronal and glial cells. However, the cell surface protein molecules are, to date, undefined. RT-PCR, immunoblotting and immunocytochemistry showed the increased expression of N-syndecan, a transmembrane heparan sulfate proteoglycan, in the neural stem cells after the differentiation induced by retinoic acid. Our data indicate that N-syndecan may be involved in the differentiation of neural stem cells. |
| Databáze: | OpenAIRE |
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