Differential gene expression profiles of human efferent ducts and proximal epididymis

Autor:	Robert Sullivan, Christine Légaré
Rok vydání:	2020
Předmět:	Epididymis Male endocrine system 030219 obstetrics & reproductive medicine Microarray analysis techniques Urology Endocrinology Diabetes and Metabolism Efferent ducts Biology Cilium assembly Cell biology Ejaculatory Ducts Transcriptome Gene expression profiling 03 medical and health sciences 0302 clinical medicine Endocrinology medicine.anatomical_structure Reproductive Medicine Gene expression medicine Humans Spermatogenesis
Zdroj:	Andrology. 8:625-636
ISSN:	2047-2927 2047-2919
Popis:	BACKGROUND Gene expression patterns along the epididymis are established by specific transcription factor networks that coordinate region-specific functions. In rodents, the epididymis can be divided in up to 19 segments. Based on gross anatomy, the human epididymis is divided into caput, corpus, and cauda segments together with efferent ducts that occupy the proximal part of this organ. OBJECTIVES To determine to which extent gene expression pattern is segmented along the efferent ducts and the proximal region of the epididymis in men of reproductive age. MATERIALS AND METHODS Epididymal transcriptome profiling was performed on eight distinct regions from three donors. Microarray analysis was performed on a gene-chip microarray. Differentially expressed genes (DEGs)>2-fold change (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c910fc37cdf02a68130e0f4a93be61f https://doi.org/10.1111/andr.12745 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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