Vaccination against Seasonal Influenza A/H3N2 Virus Reduces the Induction of Heterosubtypic Immunity against Influenza A/H5N1 Virus Infection in Ferrets
| Autor: | Ron A. M. Fouchier, Rogier Bodewes, S. E. van Trierum, Martina M. Geelhoed-Mieras, G. van Amerongen, R. J. Verburgh, Thijs Kuiken, Joost H. C. M. Kreijtz, Albert D. M. E. Osterhaus, Guus F. Rimmelzwaan |
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| Přispěvatelé: | Virology |
| Rok vydání: | 2011 |
| Předmět: |
Cross Protection
T-Lymphocytes animal diseases viruses Respiratory System Immunology Influenza A (H5N1) Virus Biology medicine.disease_cause Microbiology Virus Orthomyxoviridae Infections SDG 3 - Good Health and Well-being Immunity Virology Vaccines and Antiviral Agents Pandemic medicine Animals Heterosubtypic immunity Influenza A Virus H5N1 Subtype Histocytochemistry Influenza A Virus H3N2 Subtype Ferrets Brain virus diseases Survival Analysis Influenza A virus subtype H5N1 Vaccination Disease Models Animal Viral replication Influenza Vaccines Insect Science Female |
| Zdroj: | Journal of Virology, 85(6), 2695-2702. American Society for Microbiology |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.02371-10 |
| Popis: | Infection with seasonal influenza viruses induces a certain extent of protective immunity against potentially pandemic viruses of novel subtypes, also known as heterosubtypic immunity. Here we demonstrate that infection with a recent influenza A/H3N2 virus strain induces robust protection in ferrets against infection with a highly pathogenic avian influenza virus of the H5N1 subtype. Prior H3N2 virus infection reduced H5N1 virus replication in the upper respiratory tract, as well as clinical signs, mortality, and histopathological changes associated with virus replication in the brain. This protective immunity correlated with the induction of T cells that cross-reacted with H5N1 viral antigen. We also demonstrated that prior vaccination against influenza A/H3N2 virus reduced the induction of heterosubtypic immunity otherwise induced by infection with the influenza A/H3N2 virus. The implications of these findings are discussed in the context of vaccination strategies and vaccine development aiming at the induction of immunity to pandemic influenza. |
| Databáze: | OpenAIRE |
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