Serum Amyloid P and IgG Exhibit Differential Capabilities in the Activation of the Innate Immune System in Response to Bacillus anthracis Peptidoglycan
| Autor: | Tarea Burgett, K. Mark Coggeshall, Alanson W. Girton, Narcis I. Popescu, Ravi S. Keshari, Florea Lupu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
opsonin Immunology Fc receptor Syk Peptidoglycan Biology Microbiology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine host response serum amyloid P Humans Opsonin Host Response and Inflammation Innate immune system Monocyte Pattern recognition receptor Immunity Innate 3. Good health Complement system Cell biology Serum Amyloid P-Component 030104 developmental biology Infectious Diseases medicine.anatomical_structure chemistry inflammation Bacillus anthracis Immunoglobulin G biology.protein Parasitology 030215 immunology |
| Zdroj: | Infection and Immunity |
| ISSN: | 1098-5522 0019-9567 |
| Popis: | We showed that human IgG supported the response by human innate immune cells to peptidoglycan (PGN) from Bacillus anthracis and PGN-induced complement activation. However, other serum constituents have been shown to interact with peptidoglycan, including the IgG-like soluble pattern recognition receptor serum amyloid P (SAP). Here, we compared the abilities of SAP and of IgG to support monocyte and complement responses to PGN. Utilizing in vitro methods, we demonstrate that SAP is superior to IgG in supporting monocyte production of cytokines in response to PGN. Like IgG, the response supported by SAP was enhanced by phagocytosis and signaling kinases, such as Syk, Src, and phosphatidylinositol 3-kinase, that are involved in various cellular processes, including Fc receptor signaling. Unlike IgG, SAP had no effect on the activation of complement in response to PGN. These data demonstrate an opsonophagocytic role for SAP in response to PGN that propagates a cellular response without propagating the formation of the terminal complement complex. |
| Databáze: | OpenAIRE |
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