Imaging features of hereditary papillary renal cancers
| Autor: | Glenn Gm, W. M. Linehan, David Venzon, Irina A. Lubensky, Walther Mm, B. Zbar, Wagner, P. L. Choyke |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Diagnostic Imaging Male medicine.medical_specialty Contrast Media Cancer syndrome Text mining Region of interest Abdomen medicine Doubling time Humans Radiology Nuclear Medicine and imaging Carcinoma Renal Cell Aged Ultrasonography business.industry Syndrome Middle Aged medicine.disease Image Enhancement Magnetic Resonance Imaging Carcinoma Papillary Kidney Neoplasms Pedigree Radiographic Image Enhancement Contrast medium Injections Intravenous Female Radiology Familial Cancer business Tomography X-Ray Computed Clear cell Kidney disease Adenocarcinoma Clear Cell |
| Zdroj: | Journal of computer assisted tomography. 21(5) |
| ISSN: | 0363-8715 |
| Popis: | Purpose: Our goal was to describe the imaging features of hereditary papillary renal cancer syndrome (HPRC), a new familial cancer syndrome. Method: Members of seven kindreds with HPRC comprising 78 individuals were screened with contrast-enhanced CT and abdominal US. MRI was performed in three patients. Enhancement values and doubling times of solid masses were determined from CT scans. Results: Seventeen of 78 (22%) patients were affected. The HPRCs demonstrated lower enhancement (mean change in enhancement = 31 HU) than a comparable group of clear cell tumors (mean change in enhancement = 67 HU; p = 0.00001). The median tumor doubling time on serial CT was 18 months. The HPRCs were relatively hypovascular, enhanced uniformly, and grew slowly. Therefore, careful measurements of the region of interest should be obtained before and after intravenous administration of contrast medium. Though US detected only 45% of the lesions visualized on CT, it was useful in determining if lesions were cystic. Contrast-enhanced MRI demonstrated similar characteristics to contrast-enhanced CT. Conclusion: The tumors of patients with HPRC pose some diagnostic difficulties because they can be missed by US, are small, and enhance poorly on CT. CT is preferable to US as a screening tool because of its higher sensitivity in detecting small lesions, and when contrast media cannot be administered, MR is a suitable alternative to CT. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|