In utero myelomeningocele repair reduces intensification of inflammatory changes in the dura mater and the skin
| Autor: | Agnieszka Pastuszka, Tomasz Koszutski, Janusz Bohosiewicz, Ewa Horzelska, Jacek Zamłyński, Anita Olejek |
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| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Meningomyelocele Dura mater Group ii 030232 urology & nephrology 03 medical and health sciences Fetus 0302 clinical medicine Pregnancy Humans Medicine 030212 general & internal medicine Child Spinal Dysraphism Spinal Cord Injuries Research Articles integumentary system business.industry Spina bifida musculoskeletal system medicine.disease Spinal cord Surgery medicine.anatomical_structure nervous system In utero Gestation Female Dura Mater Neurology (clinical) business Infiltration (medical) |
| Zdroj: | J Spinal Cord Med |
| ISSN: | 2045-7723 1079-0268 |
| Popis: | Objective: Chemical and mechanical injury in myelomeningocele (MMC) during the fetal life results in functional disorders of multiple organs. Prenatal MMC repair reduces sequelae of spinal cord injury. Design: Histopathological evaluation of dura mater and skin specimens to assess the severity of inflammatory changes. Setting: Histopathological laboratory and operated patients. Participants: 45 cases (Group I)-intrauterine surgery due to MMC and 42 cases (Group II)-postnatal surgery. Outcome measures: Specimens of the skin and of the dura mater adjacent directly to the uncovered section of the spinal cord were collected for assessment. The specimens were histopathologically evaluated to assess the severity of inflammatory changes. Results: The analysis of the severity of inflammatory changes in the skin and the dura mater showed only small lymphocytic infiltration in 5 fetuses (Group I). Medium and large infiltration in the skin and the dura mater was found in all children who underwent postnatal surgery (Group II). Lymphocytic and granulocytic infiltration in the skin and the dura mater were statistically significantly more prevalent in children who underwent postnatal surgery compared to the group of children who underwent prenatal surgery (P |
| Databáze: | OpenAIRE |
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