Correlation between the plasma fibrinogen concentration and coronary heart disease severity in Moroccan patients with type 2 diabetes. Prospective study
| Autor: | Hassan Mifdal, Nabiha Kamal, Siham El Aziz, A. Farouqi, Amal Mjabber, Ayoub El Hammiri, Rachida Habbal, Bouchra Oukkache, Nadia Nourichafi, Asma Chadli, Mostafa Kabine, Souad Kotbi, N. Ghalim |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Population Coronary Disease Type 2 diabetes 030204 cardiovascular system & hematology Diabetic angiopathy Fibrinogen Severity of Illness Index Correlation 03 medical and health sciences 0302 clinical medicine Endocrinology Risk Factors Internal medicine Severity of illness medicine Humans Prospective Studies 030212 general & internal medicine Prospective cohort study education Aged Aged 80 and over education.field_of_study business.industry General Medicine Middle Aged medicine.disease Coronary heart disease Morocco Diabetes Mellitus Type 2 Cardiology Female business Diabetic Angiopathies medicine.drug |
| Zdroj: | Annales d'Endocrinologie. 77:606-614 |
| ISSN: | 0003-4266 |
| DOI: | 10.1016/j.ando.2015.02.004 |
| Popis: | Aim The present study aims at determining the relationship between the plasma fibrinogen concentration and the severity of coronary heart disease in type 2 diabetic patients. Methods Prospective analytical survey, based on a sample of 120 subjects divided in four groups: 30 non diabetic coronary patients (G1), 30 coronary diabetic patients (G2), 30 non-coronary diabetic patients (G3), and 30 healthy subjects (G4). Results The average age was 59.58 ± 7.88 years; female gender predominated by 52.5%. The plasma fibrinogen concentration corresponded to 3.46 g/L ± 0.86 in G1; 3.73 g/L ± 1.11 in G2; 3.06 g/L ± 0.98 in G3 and 2.46 g/L ± 0.51 in G4; with a significant difference between the four groups ( P = 0.001). The plasma fibrinogen concentration increased in parallel with the cardiovascular risk ( P = 0.0001); there was also a significant correlation between the plasma fibrinogen concentration and the clinical and para-clinical coronary disease severity (respectively P = 0.005 and P = 0.0001). A positive correlation between the plasma fibrinogen concentration and hyperglycemia ( P = 0.035) was found in G4. But no correlation with the lipids parameters, except for the low density-lipoproteins in G3 ( P = 0.035). Conclusion In the Moroccan population, the plasma fibrinogen concentration was positively and significantly correlated with the coronary heart disease severity. |
| Databáze: | OpenAIRE |
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