Cellular and Molecular Mechanisms of Anti-Phospholipid Syndrome
| Autor: | Debendra Pattanaik, Marko Z. Radic |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
0301 basic medicine autoantibodies Cell Immunology neutrophil extracellular traps Antigen-Antibody Complex Review 030204 cardiovascular system & hematology Extracellular Traps Pathogenesis Mice 03 medical and health sciences 0302 clinical medicine Immune system systemic lupus erythematosus Pregnancy medicine Animals Humans beta2 glycoprotein I Immunology and Allergy Genetic Predisposition to Disease Platelet phospholipids thrombosis Coagulation Protein Disorders coagulation protein disorders biology Chemistry Cell Membrane Neutrophil extracellular traps Antiphospholipid Syndrome Immunity Innate Chromatin Cell biology anti-phospholipid syndrome 030104 developmental biology medicine.anatomical_structure beta 2-Glycoprotein I Antibodies Antiphospholipid biology.protein Female Antibody lcsh:RC581-607 Signal Transduction |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 9 (2018) |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2018.00969 |
| Popis: | The primary anti-phospholipid syndrome (APS) is characterized by the production of antibodies that bind the phospholipid-binding protein β2 glycoprotein I (β2GPI) or that directly recognize negatively charged membrane phospholipids in a manner that may contribute to arterial or venous thrombosis. Clinically, the binding of antibodies to β2GPI could contribute to pathogenesis by formation of immune complexes or modification of coagulation steps that operate along cell surfaces. However, additional events are likely to play a role in pathogenesis, including platelet and endothelial cell activation. Recent studies focus on neutrophil release of chromatin in the form of neutrophil extracellular traps as an important disease contributor. Jointly, the participation of both the innate and adaptive arms of the immune system in aspects of the APS make the complete understanding of crucial steps in pathogenesis extremely difficult. Only coordinated and comprehensive analyses, carried out in different clinical and research settings, are likely to advance the understanding of this complex disease condition. |
| Databáze: | OpenAIRE |
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