Simvastatin inhibits the core promoter of the TXNRD1 gene and lowers cellular TrxR activity in HepG2 cells
| Autor: | Katalin Monostory, Lena Ekström, Maria Johansson, Elias S.J. Arnér, Anna Klara Rundlöf, Linda Björkhem-Bergman |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Simvastatin
Thioredoxin Reductase 1 Indoles Atorvastatin Thioredoxin reductase Biophysics Stimulation Biology Pharmacology medicine.disease_cause Biochemistry Fatty Acids Monounsaturated medicine Animals Humans RNA Messenger cardiovascular diseases Fluvastatin Promoter Regions Genetic Molecular Biology chemistry.chemical_classification nutritional and metabolic diseases Hep G2 Cells Cell Biology Rats Enzyme chemistry Hepatocytes lipids (amino acids peptides and proteins) Hydroxymethylglutaryl-CoA Reductase Inhibitors Carcinogenesis medicine.drug |
| Zdroj: | Biochemical and Biophysical Research Communications. 430:90-94 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2012.11.007 |
| Popis: | Thioredoxin reductase 1 (TrxR1) is a selenocysteine-containing redox-active enzyme that is thought to be important during carcinogenesis. We have recently shown that treatment with statins, HMGCoA reductase inhibitors, reduces the levels of TrxR1 in liver of both rat and human. The reduced TrxR1 levels were correlated with inhibited hepatocarcinogenesis in a rat model. The aim of the present study was to investigate if statins affect the activity of the human TXNRD1 core promoter, which guides expression of TrxR1, and if the effects by statins on TrxR1 expression in liver could be reproduced in a cellular model system. We found that simvastatin and fluvastatin decreased cellular TrxR activity in cultured human liver-derived HepG2 cells with approximately 40% (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect