The size and depth of lesions measured by endoscopic ultrasonography are novel prognostic factors of primary gastric diffuse large B-cell lymphoma
| Autor: | Qun Ling Zhang, Chun Yan Li, Xiao Jian Liu, Bo Shi Wang, Yi Zhen Liu, Xiaonan Hong, Jiachen Wang, Hui Sun, Zu Guang Xia, Jun Ning Cao, Dong Mei Ji, Jia Jin, Kai Xue, Fang Fang Lv |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Endoscopic ultrasound Cancer Research Pathology medicine.medical_specialty Adolescent Kaplan-Meier Estimate Endoscopic ultrasonography Endosonography Young Adult 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms immune system diseases hemic and lymphatic diseases Antineoplastic Combined Chemotherapy Protocols medicine Humans Neoplasm Invasiveness Aged Neoplasm Staging Proportional Hazards Models Aged 80 and over medicine.diagnostic_test business.industry Lymphoma Non-Hodgkin Hematology Middle Aged Prognosis medicine.disease Oncology 030220 oncology & carcinogenesis Female Lymphoma Large B-Cell Diffuse Primary Gastric Diffuse Large B-Cell Lymphoma business Diffuse large B-cell lymphoma 030215 immunology |
| Zdroj: | Leukemia & Lymphoma. 60:934-939 |
| ISSN: | 1029-2403 1042-8194 |
| Popis: | Diffuse large B cell lymphoma is one of the predominant histological subtypes of primary gastric lymphomas. Factors that contribute to precise stratification and guide the treatment of this disease are still not well understood. We analyzed 73 primary gastric diffuse large B cell lymphoma patients retrospectively, and found that patients characterized by late stage, multiple localization, B symptoms, lower serum albumin level and elevated LDH level had a shorter overall survival through Univariate Cox regression analysis. Multivariate Cox regression analysis demonstrated that ALB ≤ 35g/L, staging ≥ IIE and multiple sites localization were independent adverse prognostic factors. Significantly, in 35 patients who received endoscopy at diagnosis, Kaplan-Meier analyses indicated that patients with large (≥3 cm) and deep lesions (≥11 mm) had an inferior OS (p = .01 and .039). These findings implicated that tumor size and depth are two indicators of prognosis under ultrasonography. Further randomized studies with large number of cases are needed. |
| Databáze: | OpenAIRE |
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